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Eicosapentaenoic acid and protein modulation to induce anabolism in COPD

Description: PROJECT NARRATIVE The results of this study should provide the basis for a new nutritional formulation to support protein anabolism and improve overall outcome in cachectic patients with Chronic Obstructive Pulmonary Disease.
Funding type: research
Funder scheme: R01
Start date: 2009-08-06
End date: 2015-06-30
Investigator: NICOLAAS E DEUTZ
Institution: TEXAS A&M UNIVERSITY
Field: Medicine
Funded outputs count: 21
Funder award ID: R01HL095903
OpenAlex ID: G1054943557
Biological sex and age‐associated changes in muscle and brain health in Chronic Obstructive Pulmonary Disease: A large cross‐sectional study
2025 · Minchae C. Kang, Nicolaas E. P. Deutz, et al. · Nutrition in Clinical Practice · 6
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Metabolic kinetics and muscle and brain health markers in older adults, and the role of age and presence of chronic morbidities: A large cross-sectional cohort study
2024 · Minchae C. Kang, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 10
Reduced plasma glycine concentration in healthy and chronically diseased older adults: a marker of visceral adiposity?
2024 · Lars NJ Deutz, Raven A Wierzchowska-McNew, et al. · American Journal of Clinical Nutrition · 6
Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease
2023 · Mariëlle P.K.J. Engelen, Sarah K. Kirschner, et al. · Clinical Nutrition · 22
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ω-3 polyunsaturated fatty acid supplementation improves postabsorptive and prandial protein metabolism in patients with chronic obstructive pulmonary disease: a randomized clinical trial
2022 · Mariëlle PKJ Engelen, Renate Jonker, et al. · American Journal of Clinical Nutrition · 37
Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein
2018 · Renate Jonker, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 20
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Preserved anabolic threshold and capacity as estimated by a novel stable tracer approach suggests no anabolic resistance or increased requirements in weight stable COPD patients
2018 · Renate Jonker, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 18
A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans
2017 · Alvise Mason, Mariëlle P. K. J. Engelen, et al. · American Journal of Physiology-Endocrinology and Metabolism · 31
24-Hour protein, arginine and citrulline metabolism in fed critically ill children – A stable isotope tracer study
2017 · Carlijn T.I. de Betue, Xiomara C. Garcia Casal, et al. · Clinical Nutrition · 22
Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults
2016 · Renate Jonker, Nicolaas EP Deutz, et al. · Metabolism · 50
Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry
2016 · Dillon K. Walker, John J. Thaden, et al. · Journal of Chromatography B · 16
Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease
2016 · Renate Jonker, Nicolaas EP Deutz, et al. · American Journal of Clinical Nutrition · 45
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Protein anabolic resistance in cancer
2015 · Mariëlle P.K.J. Engelen, Barbara S. van der Meij, et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 52
Application of gas chromatography–tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water
2015 · Dillon K. Walker, John J. Thaden, et al. · Journal of Mass Spectrometry · 8
Protein is an important but undervalued macronutrient in the nutritional care of patients with cystic fibrosis
2014 · Mariëlle P.K.J. Engelen, Gulnur Com, et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 53
Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group
2014 · Nicolaas E.P. Deutz, Jürgen M. Bauer, et al. · Clinical Nutrition · 1,736
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Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion
2013 · Renate Jonker, Nicolaas E.P. Deutz, et al. · Clinical Nutrition · 55
Is there a maximal anabolic response to protein intake with a meal?
2012 · Nicolaas E. Deutz, Robert R. Wolfe · Clinical Nutrition · 142
Role of specific dietary amino acids in clinical conditions
2012 · Renate Jonker, Mariëlle P. K. J. Engelen, et al. · British Journal Of Nutrition · 71
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Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids
2012 · M.P.K.J. Engelen, C.L.N. De Castro, et al. · Clinical Nutrition · 52
Casein protein results in higher prandial and exercise induced whole body protein anabolism than whey protein in Chronic Obstructive Pulmonary Disease
2012 · Mariëlle P.K.J. Engelen, Erica P.A. Rutten, et al. · Metabolism · 22
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