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Johns Hopkins Alzheimer's Disease Research Center

Description: OVERALL – PROJECT NARRATIVE The Johns Hopkins Alzheimer’s Disease Research Center is an integrated program aimed at finding improved treatments for individuals with Alzheimer disease and related disorders. Complimentary activities within the center include clinical and basic research studies that contribute significantly to national programs. In addition, the Center is dedicated to training the next generation of investigators and to reaching out to the community to improve understanding about these diseases.

Funder: National Institute on Aging

Funding type: program

Funder scheme: P30

Start date: 2020-04-15

End date: 2030-03-31

Investigator: MARILYN S. ALBERT (lead)

Institution: Johns Hopkins University

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Funded outputs count: 1,161

Funder award ID: P30AG066507

OpenAlex ID: G9000888980

Imipramine binds to amyloid-β and extends the survival of Alzheimer’s disease patients

2026 · Noah R. Johnson, James Beham, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Measurement precision matters: Accounting for uncertainty alters estimated memory trajectories across the cognitive spectrum

2026 · Emily H. Trittschuh, Phoebe Scollard, et al. · Alzheimer s & Dementia

Alzheimer’s pathology mediates arteriolosclerosis and cerebral amyloid angiopathy associations with cognition

2026 · Cellas A Hayes, Anhiti Dharmapuri, et al. · Brain

Feature harmonization reveals that apparent cross-cohort differences in tau-positivity prediction reflect variable availability and cohort stage structure

2026 · Avinay Bhat, Mattia Cestari, et al. · medRxiv

Reply: Clarifying incremental accuracy and thresholds for a plasma tau-to-amyloid ratio

2026 · Natalya Benina, Luna Buitrago, et al. · Brain

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

2026 · Sara Ho, Ziling Shen, et al. · Annals of Clinical and Translational Neurology

Charting Cervical Spinal Cord Morphometry Across the Lifespan

2026 · Kurt G. Schilling, Michael E. Kim, et al. · Human Brain Mapping

Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes

2026 · Jacob Ziontz, Ganna Blazhenets, et al. · Annals of Neurology

Vision Impairment, Vision Correction, and Dementia Risk in Mild Cognitive Impairment

2026 · Huilin Tang, David A. Wolk, et al. · Journal of the American Geriatrics Society

Incident versus prevalent progressive supranuclear palsy: analyses of U.S. Alzheimer’s Disease Research Centers data indicate clinical and neuropathological features of a relatively common and underrecognized tauopathy in the aging brain

2026 · Benjamin J. Cushing, Ryan K. Shahidehpour, et al. · Acta Neuropathologica

dMRI-F: A Foundation Model for Generalizable Diffusion MRI Analysis from Sparse Acquisitions

2026 · Zhu, Xi, Li, Yijie, et al. · arXiv (Cornell University)

Fine-tuning genomic models on rare splicing events identifies a novel biomarker of TDP-43 pathology

2026 · Cristina P. Martin-Linares, Aswathy Peethambaran Mallika, et al. · bioRxiv (Cold Spring Harbor Laboratory)

HINN prioritizes multi-omics biomarkers associated with cognitive decline

2026 · Yashu Vashishath, Sarah Anne Beaver, et al. · Bioinformatics · 1

Sex‐specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia

2026 · Xulin Liu, Sterre C. M. de Boer, et al. · Alzheimer s & Dementia

Attention‐deficit/hyperactivity disorder polygenic risk score and incidence of cognitive impairment in older adults: A prospective multicohort study

2026 · Douglas Teixeira Leffa, Guilherme Bauer‐Negrini, et al. · Alzheimer s & Dementia

Symmetric Centipolar Normalized Score (SCeNS): A standardization framework for fluid marker cross‐comparability in Alzheimer's disease

2026 · Jigyasha Timsina, Yike Chen, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Mini‐Mental State Examination trajectories across dementia subtypes in the Swedish Registry for Cognitive/Dementia Disorders and U.S. National Alzheimer's Coordinating Center

2026 · Xinqi Bao, Belén García Pascual, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Remote versus in‐person cognitive testing: the impact of visit modality on longitudinal cognitive outcomes in older adults

2026 · Yu Leng, Yingnan He, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Explainable AI framework for Alzheimer’s disease prediction using multimodal data

2026 · Aunsia Khan, Anusha Achuthan, et al. · Scientific Reports

Diagnostic Utility of Multi-Domain Language Measures Across the Alzheimer Disease Continuum

2026 · Zihao Geng, Maxime Montembeault, et al. · medRxiv

Optimal cutoffs for the Montreal Cognitive Assessment among English and Spanish speaking Latinos

2026 · Jaime Perales-Puchalt, Andrew J. Aschenbrenner, et al. · Applied Neuropsychology Adult

APOE4 differentially alters lipid composition in extracellular vesicles from hiPSC-derived neurons of Alzheimer’s disease patients

2026 · Marios G. Krokidis, Ram Sagar, et al. · Frontiers in Pharmacology

Using machine learning of neuroimaging and mitochondrial haplogroups to predict maternal family history of Alzheimer’s disease

2026 · Olivia J. Veatch, Sreejata Dutta, et al. · PLOS Aging and Health

Charting confidence in white matter brain charts: enabling study planning through stability validation

2026 · Michael E. Kim, Gaurav Rudravaram, et al. · Journal of medical imaging

Assessing Microstructural and Molecular Brain Changes in Early Cognitive Decline Using Multiparametric 3T Magnetic Resonance Imaging

2026 · Zongpai Zhang, Jingpu Wu, et al. · Neurology International