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Caloric Restriction and Aging in Rhesus Monkeys

Description: PUBLIC HEALTH RELEVANCE: Our rapidly growing aging population deems interventions that delay or prevent age-associated disease to be of huge public health significance. Caloric restriction (less calories eaten but without a shortage of essential nutrients) opposes a broad array of age-associated health problems in monkeys. This 25-year-long project will establish the impact of CR on lifespan and discover how CR extends healthy aging.
Funding type: research
Funder scheme: R01
Start date: 2011-09-30
End date: 2021-02-28
Investigator: ROZALYN M. ANDERSON
Institution: UNIVERSITY OF WISCONSIN-MADISON
Subfield: Aging
Funded outputs count: 55
Funder award ID: R01AG040178
OpenAlex ID: G8300099175
Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys
2025 · Salma I Abou Elhassan, Josef P Clark, et al. · Molecular Systems Biology · 1
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Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys
2025 · Josef P Clark, Timothy W Rhoads, et al. · Aging Cell · 3
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Mass Spectrometry-Based Multiomics Identifies Metabolic Signatures of Sarcopenia in Rhesus Monkey Skeletal Muscle
2023 · Melissa R. Pergande, Katie J. Osterbauer, et al. · Journal of Proteome Research · 8
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Detrusor underactivity is associated with metabolic syndrome in aged primates
2023 · Natalia P. Biscola, Petra M. Bartmeyer, et al. · Scientific Reports · 5
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Ceramides are early responders in metabolic syndrome development in rhesus monkeys
2022 · Alex B. Smith, Jonah P. Schill, et al. · Scientific Reports · 8
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Resilience integrates concepts in aging research
2022 · Daniel Promislow, Rozalyn M. Anderson, et al. · iScience · 37
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Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
2022 · Priya Balasubramanian, Anne E. Schaar, et al. · eLife · 50
Fasting blood glucose as a predictor of mortality: Lost in translation
2021 · Dushani L. Palliyaguru, Eric J. Shiroma, et al. · Cell Metabolism · 81
Rhesus monkeys as a translational model for late‐onset Alzheimer's disease
2021 · Dylan C. Souder, Isabelle A. Dreischmeier, et al. · Aging Cell · 25
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Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques
2020 · Leif A. Havton, Natalia P. Biscola, et al. · PLoS ONE · 8
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Alpha-Ketoglutarate, the Metabolite that Regulates Aging in Mice
2020 · Timothy W. Rhoads, Rozalyn M. Anderson · Cell Metabolism · 36
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Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice
2020 · Miguel A. Aon, Michel Bernier, et al. · Cell Metabolism · 147
Age-Related Differences in the Gut Microbiome of Rhesus Macaques
2020 · Julie Adriansjach, Scott T Baum, et al. · The Journals of Gerontology Series A · 52
Molecular and Functional Networks Linked to Sarcopenia Prevention by Caloric Restriction in Rhesus Monkeys
2020 · Timothy W. Rhoads, Josef P. Clark, et al. · Cell Systems · 50
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Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys
2019 · Niranjana Natarajan, Ana Vujic, et al. · JCI Insight · 7
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Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle
2019 · Yutong Jin, Gary M. Diffee, et al. · Journal of the American Society for Mass Spectrometry · 33
Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys
2018 · Timothy W. Rhoads, Maggie S. Burhans, et al. · Cell Metabolism · 81
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Caloric restriction delays age-related methylation drift
2017 · Shinji Maegawa, Yue Lu, et al. · Nature Communications · 283
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Metabolic adventures in aging research
2017 · Holly M. Brown-Borg, Rozalyn M. Anderson · Molecular and Cellular Endocrinology · 2
Non-human primates as a model for aging
2017 · Ricki J. Colman · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 155
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Caloric restriction impacts plasma micro RNA s in rhesus monkeys
2017 · Augusto Schneider, Joseph M. Dhahbi, et al. · Aging Cell · 29
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Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential
2017 · Priya Balasubramanian, Porsha R. Howell, et al. · EBioMedicine · 148
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Nutrition modulation of human aging: The calorie restriction paradigm
2017 · Sai Krupa Das, Priya Balasubramanian, et al. · Molecular and Cellular Endocrinology · 51
Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study
2017 · Yosuke Yamada, Joseph W Kemnitz, et al. · The Journals of Gerontology Series A · 60
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Hepatic Metabolic Reprogramming by Caloric Restriction in Rhesus Monkeys
2017 · Timothy W. Rhoads, Maggie S. Burhans, et al. · The FASEB Journal
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