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Effectors of Cellular Senescence States

Description: Narrative Retrotransposable elements are viral-like entities that exist within the DNA of our cells. During aging these molecular parasites are prone to activation, with deleterious effects on their host cells, such as inflammation. Our goal is to develop drugs to block these elements, which we expect will alleviate age-associated diseases.
Funding type: research
Funder scheme: R01
Start date: 1999-04-01
End date: 2026-03-31
Investigator: JOHN M SEDIVY
Institution: BROWN UNIVERSITY
Subfield: Physiology
Field: Medicine
Funded outputs count: 54
Funder award ID: R01AG016694
OpenAlex ID: G7828299355
cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation
2026 · John C. Martinez, Francesco Morandini, et al. · Nature Aging · 14
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Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming Innovations
2026 · Sukanta Jash, John M Sedivy · Biomedicines
Characterization of Cellular Senescence in Primary Human Astrocytes
2026 · Trenton A. Woodham, Maxfield M.G. Kelsey, et al. · bioRxiv (Cold Spring Harbor Laboratory)
The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNA
2026 · Maxfield M.G. Kelsey, Radha L. Kalekar, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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RNA transcripts in salivary extracellular vesicle cargo isolated from aged populations
2026 · Sicheng Wen, Chang Yu, et al. · Frontiers in Aging · 2
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Senolytic reduction of senescent cells mitigates atrial arrhythmia vulnerability in aging rabbits
2026 · Elif Sengun, Lily Zhou, et al. · Heart Rhythm · 1
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Retrotransposon Activation in the Aged and Alzheimer’s Disease Brain Examined by Nanopore Long-read DNA Sequencing
2025 · Maxfield M.G. Kelsey, Anjalika Chongtham, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Rapid DNA cleavage by the LINE-1 endonuclease proximal to DNA ends and at mismatches
2025 · Bryant D. Miller, Benedict A. Smail, et al. · Journal of Biological Chemistry · 6
TE-Seq: a transposable element annotation and RNA-Seq pipeline
2025 · Maxfield M.G. Kelsey, Radha L. Kalekar, et al. · Mobile DNA · 10
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Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?
2025 · Zhixun Dou, Jill A Kreiling, et al. · The EMBO Journal · 16
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Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation
2025 · Audrey Dalgarno, Shane A. Evans, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
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A transcriptomic score to classify the inflammation-dysplasia-cancer sequence lesions in inflammatory bowel disease
2025 · Anneline Cremer, Nicolas Rosewick, et al. · Journal of Crohn s and Colitis · 2
Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
2024 · Alexandra M. D’Ordine, Gerwald Jogl, et al. · Nature Communications · 13
Proceedings of the inaugural Dark Genome Symposium: November 2022
2023 · Jef D. Boeke, Kathleen H. Burns, et al. · Mobile DNA · 4
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Regulation of the somatotropic axis by MYC-mediated miRNA repression
2023 · Anna P. Petrashen, Andrew D. Verdesca, et al. · Frontiers in Cell and Developmental Biology · 3
Single-Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity across Different Forms of Cellular Senescence
2023 · Nicola Neretti, Shane A. Evans, et al. · 13
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Analysis of Somatic Mutations in Senescent Cells Using Single-Cell Whole-Genome Sequencing
2023 · Lei Zhang, Marco De Cecco, et al. · 10
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Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart
2023 · Brett C. Baggett, Kevin R. Murphy, et al. · eLife · 12
LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq
2023 · Wilson McKerrow, Larisa Kagermazova, et al. · Nucleic Acids Research · 30
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Loss of epigenetic information as a cause of mammalian aging
2023 · Jae-Hyun Yang, Motoshi Hayano, et al. · Cell · 643
Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
2022 · Matthew A. Romero, Petey W. Mumford, et al. · Exercise and Sport Sciences Reviews · 4
Sirt6 regulates lifespan in Drosophila melanogaster
2022 · Jackson R. Taylor, Jason G. Wood, et al. · Proceedings of the National Academy of Sciences · 55
The role of retrotransposable elements in ageing and age-associated diseases
2021 · Vera Gorbunova, Andrei Seluanov, et al. · Nature · 428
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
2021 · Xudong Zhu, Zhiyang Chen, et al. · Signal Transduction and Targeted Therapy · 399
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Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain
2021 · Jocelyn C. Newton, Mandar T. Naik, et al. · Biophysical Journal · 48
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