Biomaterials-directed regenerative immunotherapies
Description: Narrative Tissue loss due to trauma, disease or congenital abnormalities remains an intractable clinical challenge, and there are profound deficits in how humans heal and recover from tissue damage and few innovations in regenerative medicine have reached the clinic or improved standard of care. Formation of dysfunctional scar tissue remains the default pathway for repair in the body; the immune system is the first responder to trauma yet this response, and its capacity to orchestrate tissue repair, has been largely ignored. We propose to develop regenerative immunotherapies that engage and manipulate the immune system to promote tissue repair.
Funding type: grant
Funder scheme: DP1
Start date: 2019-09-25
End date: 2025-08-31
Investigator: JENNIFER H ELISSEEFF
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 32
Funder award ID: DP1AR076959
OpenAlex ID: G1404759878