Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Trial
Description: PROJECT NARRATIVE Treatment resistant depression (TRD) in older adults is a leading cause of disability, dementia, and poor quality of life. Deficient slow waves sleep is at the nexus of depression and cognitive dysfunction in older adults, but novel treatments have not targeted this core pathophysiology. These combined Phase 1 and Phase 2 mechanistic clinical trials will investigate whether propofol confers slow wave sleep enhancement, resulting in longer-term improvements to sleep structure, cognitive function, and mood.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2022-02-01
End date: 2027-01-31
Investigator: ERIC J LENZE
Institution: WASHINGTON UNIVERSITY
Funded outputs count: 13
Funder award ID: U01MH128483
OpenAlex ID: G9000882231