Continued follow-up of the Vitamin C and Smoking in Pregnancy (VCSIP) cohorts through the ECHO consortium, focus on Echo-wide protocols, respiratory outcomes, airway function, and epigenetic changes
Description: Project Narrative This application is to renew our successful participation in the Environmental influences on Children's Health Outcomes (ECHO) Program for an additional seven years (9/2023-8/2030). For this renewal, we will leverage the robust ECHO cohorts with airway-specialized outcomes questionnaires) (MSDP) exposures. (yearly spirometry and twice-yearly respiratory to characterize t he relationships between feta exposure to maternal smoking during pregnancy on airway function and wheeze during childhood as modified by multi-factorial prenatal and postnatal W l e will also leverage ECHO Cohort Protocol 3.0 core data elements to characterize the epigenetic signatures in placenta and offspring associated with MSDP, and examine their additive predictive value relative to additional prenatal and postnatal exposures.
Funder: National Institutes of Health
Funding type: cooperative_agreement
Funder scheme: UH3
Start date: 2016-09-21
End date: 2030-05-31
Investigator: CYNTHIA T MCEVOY
Institution: OREGON HEALTH & SCIENCE UNIVERSITY
Funded outputs count: 149
Funder award ID: UH3OD023288
OpenAlex ID: G9000875915