Award

The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC)

Description: PROJECT NARRATIVE OVERALL Senescence refers to the loss of cell function with aging and is associated with many chronic diseases of aging, but the mechanisms by which this happens is poorly understood at a molecular level. The proposed project seeks to advance knowledge of the molecular features of senescence through cutting-edge profiling techniques and mouse resources that will complement efforts at the human level to map senescence in human cells and tissues.
Funding type: cooperative_agreement
Funder scheme: U54
Start date: 2022-08-15
End date: 2027-07-31
Investigator: RONNY KORSTANJE
Institution: JACKSON LABORATORY
Funded outputs count: 16
Funder award ID: U54AG079753
OpenAlex ID: G9000909195
2026 · Gretchen T. Clark, Yue Zhao, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Sumiran Kasturi, Arnold M Salazar, et al. · The Journals of Gerontology Series A
2025 · Sheng Li, Paula A. Agudelo Garcia, et al. · Nature Genetics · 40
2025 · Laura Reinholdt, Elissa Chesler, et al. · Trends in Genetics · 6
2024 · Yue Zhao, Dylan Agyemang, et al. · Science Advances · 11
2024 · Nathan S. Gasek, Pengyi Yan, et al. · Nature Aging · 43
2024 · Vidyani Suryadevara, Adam D. Hudgins, et al. · Nature Reviews Molecular Cell Biology · 409
2024 · Yue Zhao, Hash Brown Taha, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2024 · Jenna M. Bartley, Ming Xu · Nature Aging · 5
2023 · Cara C. Hardy, Ron Korstanje · Aging Cell · 25
2022 · Rachel L. Cohn, Nathan S. Gasek, et al. · Trends in Cell Biology · 292
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