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Cancer Epidemiology Cohort in Male Health Professionals

Description: The goal of this proposal is to continue the follow-up of HPFS, the only large cohort of men with biomarkers and repeated measures of diet, physical activity, and other exposures over several decades, now in a maximally informative phase and is a unique resource for scientific aims that integrate diet and other environmental variables, biomarkers, genetic predisposition and mediating variables in relation to cancer.
Funding type: cooperative_agreement
Funder scheme: UM1
Start date: 2012-08-21
End date: 2017-08-15
Investigator: WALTER C. WILLETT
Institution: HARVARD SCHOOL OF PUBLIC HEALTH
Funded outputs count: 449
Funder award ID: UM1CA167552
OpenAlex ID: G7908535992
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation
2026 · Pushpamali De Silva, Samantha Fitzgerald, et al. · Science Advances
Tumor Vascular Features and Colorectal Cancer–Specific Mortality
2026 · Kosuke Matsuda, Satoshi Miyahara, et al. · JAMA Network Open
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MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle
2026 · Jiayin Zheng, Robert S Steinfelder, et al. · medRxiv
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TGF-β Pathway–Based Polygenic Risk Score Modifies the Association between Red Meat Intake and Colorectal Cancer Risk: Application of a Novel Pathway-Based PRS Method
2026 · Joel Sanchez Mendez, Bryan Queme, et al. · Cancer Epidemiology Biomarkers & Prevention · 1
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Genetic risk factors modulate the association between physical activity and colorectal cancer
2026 · Anita R. Peoples, Mireia Obón-Santacana, et al. · BMC Medicine · 2
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Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer
2025 · Carino Gurjao, Jules Cazaubiel, et al. · Cancer Epidemiology Biomarkers & Prevention · 1
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Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
2025 · Tabitha A. Harrison, Syed H. Zaidi, et al. · BMC Cancer
T-cell Subset Features and Distributions Evolve across the Colorectal Precancer–Cancer Spectrum
2025 · Yasutoshi Takashima, Andressa Dias Costa, et al. · Cancer Immunology Research · 5
Multiple polygenic score approach in colorectal cancer risk prediction
2025 · Shangqing Joyce Jiang, Minta Thomas, et al. · Scientific Reports · 2
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Using gene-environment interactions to explore pathways for colorectal cancer risk
2025 · Emmanouil Bouras, Ren Yu, et al. · EBioMedicine · 3
Risk of Diabetes in Individuals with Kidney Stones
2025 · Megan Prochaska, Pietro Manuel Ferraro, et al. · Clinical Journal of the American Society of Nephrology
Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction
2025 · W. James Gauderman, Yubo Fu, et al. · PLoS Genetics · 16
Smoking habit and long-term colorectal cancer incidence by exome-wide mutational and neoantigen loads: evidence based on the prospective cohort incident-tumour biobank method
2025 · Tsuyoshi Hamada, Tomotaka Ugai, et al. · BMJ Oncology · 13
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Associations between Calcium Intake and T-cell Infiltration in Colorectal Tumors
2025 · Evertine Wesselink, Claire E. Thomas, et al. · Cancer Prevention Research · 1
Mendelian randomization study of sleep traits and risk of colorectal cancer
2025 · Olympia Dimopoulou, Harriett Fuller, et al. · Scientific Reports · 3
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Density of T-cell Subsets in Colorectal Cancer in Relation to Disease-Specific Survival
2025 · Claire E. Thomas, Yasutoshi Takashima, et al. · Cancer Epidemiology Biomarkers & Prevention · 3
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Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
2025 · Saleh Alduhayh, Ruhina Shirin Laskar, et al. · Cancer Epidemiology Biomarkers & Prevention · 3
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Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment
2025 · Mai Chan Lau, Jennifer Borowsky, et al. · PLoS Computational Biology · 9
Long-term yogurt intake and colorectal cancer incidence subclassified by Bifidobacterium abundance in tumor
2025 · Satoko Ugai, Li Liu, et al. · Gut Microbes · 17
Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
2025 · Christos V. Chalitsios, Georgios Markozannes, et al. · Cancer Epidemiology Biomarkers & Prevention · 1
Proinflammatory Dietary Pattern and the Risk of Female Gout: Sex‐Specific Findings From Three Prospective Cohort Studies
2025 · Sharan K. Rai, Hyon K. Choi, et al. · Arthritis & Rheumatology · 5
Monounsaturated fatty acids from plant or animal sources and risk of type 2 diabetes in three large prospective cohorts of men and women
2025 · Zhangling Chen, Frank Qian, et al. · Diabetologia · 7
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The subtype-free average causal effect for heterogeneous disease etiology
2025 · A Sasson, M Wang, et al. · Biometrics · 2
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Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors
2024 · Claire E. Thomas, Yasutoshi Takashima, et al. · Frontiers in Immunology · 11
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Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
2024 · W. James Gauderman, Yubo Fu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 4
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