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Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging

Description: PROJECT NARRATIVE There is an urgent need for Biomarkers of Aging to predict and monitor age-related conditions and complex phenotypes of aging. We propose to develop robust biomarkers and high-throughput proteomics assays for proteins that are regulated and secreted during cellular senescence. After thorough validation of these candidates as biomarkers of aging they will be quantitatively measured in plasma and plasma exosomes from human aging cohorts, and subsequently correlated to aging and specific health outcomes.

Funder: National Institute on Aging

Funding type: cooperative_agreement

Funder scheme: U01

Start date: 2018-09-30

End date: 2024-04-30

Investigator: BIRGIT SCHILLING

Institution: BUCK INSTITUTE FOR RESEARCH ON AGING

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 41

Funder award ID: U01AG060906

OpenAlex ID: G6699030913

Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging

2026 · Charles A. Schurman, Joanna Bons, et al. · Bone Research · 8

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction

2025 · Francesco Neri, Shuyuan Zheng, et al. · Aging · 6

Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures

2025 · Sandip Kumar Patel, Joanna Bons, et al. · Aging · 16

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)

2025 · Sudipta Bar, Tyler A.U Hilsabeck, et al. · Aging · 3

Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior

2025 · Jordan B. Burton, Philippe Gascard, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts

2025 · Huixun Du, Jacob P. Rose, et al. · GeroScience · 16

Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube

2024 · Ashleigh J. Crawford, André Forjaz, et al. · Science Advances · 26

Challenges and recommendations for the translation of biomarkers of aging

2024 · Chiara M. S. Herzog, Ludger J. E. Goeminne, et al. · Nature Aging · 111

Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrest

2024 · Francesco Neri, Shuyuan Zheng, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7

A Fully-Automated Senescence Test (FAST) for the high-throughput quantification of senescence-associated markers

2024 · Francesco Neri, Selma N. Takajjart, et al. · GeroScience · 17

SenNet recommendations for detecting senescent cells in different tissues

2024 · Vidyani Suryadevara, Adam D. Hudgins, et al. · Nature Reviews Molecular Cell Biology · 409

Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure

2024 · Kohsaku Numa, Sandip Kumar Patel, et al. · Aging · 6

Regulation of urea cycle by reversible high-stoichiometry lysine succinylation

2024 · Ran Zhang, Jingqi Fang, et al. · Nature Metabolism · 28

Proteomic Analysis of the Senescence-Associated Secretory Phenotype: GDF-15, IGFBP-2, and Cystatin-C Are Associated With Multiple Aging Traits

2023 · Daniel S Evans, Danielle Young, et al. · The Journals of Gerontology Series A · 73

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

2023 · Andrés Fuentes‐Flores, Cristian Geronimo‐Olvera, et al. · EMBO Molecular Medicine · 75

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

2023 · Jayanta Kumar Das, Nirad Banskota, et al. · Aging Cell · 70

Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease

2023 · Jacob P. Rose, Charles A. Schurman, et al. · PLoS ONE · 20

Cellular Senescence Exacerbates Features of Aging in the Eyes

2023 · Koji Kitazawa, Judith Campisi, et al. · 13

Precision-engineered biomimetics: the human fallopian tube

2023 · Ashleigh J. Crawford, André Forjaz, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 8

Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

2023 · R. Waziry, C. P. Ryan, et al. · Nature Aging · 95

Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium

2023 · Xu Zhang, Daniel J Tyrrell, et al. · The Journals of Gerontology Series A · 1

Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease

2023 · Charles A. Schurman, Jordan B. Burton, et al. · Journal of Bone Metabolism · 33

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

2023 · R. Waziry, C. P. Ryan, et al. · Nature Aging · 190

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

2023 · Jina Yun, Simon Hansen, et al. · Nature Communications · 73

Role of the Senescence-Associated Factor Dipeptidyl Peptidase 4 in the Pathogenesis of SARS-CoV-2 Infection

2023 · Stefanie Deinhardt-Emmer, Sharvari Deshpande, et al. · Aging and Disease · 11