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Mechanisms of Oxytocins Analgesia in Older Adults

Description: PROJECT NARRATIVE Osteoarthritis (OA) represents the leading cause of disability worldwide in individuals aged 65 and older with very limited effective treatment options and the neuropeptide oxytocin (OT) may be a promising treatment for this population. The proposed research aims to determine OT's pain-relieving effects in older individuals with chronic knee OA pain thereby determining the individual characteristics that account for response to treatment. Results stemming from this work have the potential to help pave the way for future investigations using a treatment optimization strategy for older individuals with chronic pain.
Funding type: research
Funder scheme: R01
Start date: 2018-08-01
End date: 2025-04-30
Investigator: YENISEL CRUZ-ALMEIDA
Institution: UNIVERSITY OF FLORIDA
Field: Psychology
Funded outputs count: 80
Funder award ID: R01AG059809
OpenAlex ID: G157864332
2026 · Kylie A. Wright, Marilyn Horta, et al. · Neuroscience & Biobehavioral Reviews
2026 · Taylor C. Judkins, Hailey J. Andrews, et al. · Frontiers in Dementia
2025 · Kylie A. Wright, Rebecca J. Polk, et al. · Journal of Neuroendocrinology · 2
2025 · Javier A. Tamargo, Yenisel Cruz-Almeida · Journal of Pain Research · 3
2025 · Javier A. Tamargo, Glenn Smith, et al. · Journal of Pain · 2
2025 · Soamy Montesino-Goicolea, Pedro Antonio Valdes-Hernandez, et al. · medRxiv · 2
2024 · Shanshan Xiao, Håkan Fischer, et al. · Comprehensive Psychoneuroendocrinology · 2
2024 · Javier A Tamargo, Larissa J Strath, et al. · The Journals of Gerontology Series A · 17
2024 · Javier A. Tamargo, Yenisel Cruz-Almeida · Social Science & Medicine · 13
2024 · Kamelia Klejc, Yenisel Cruz-Almeida, et al. · Journal of Pain Research · 3
2024 · Marilyn Horta, Alayna Shoenfelt, et al. · Scientific Reports
2023 · Alayna Shoenfelt, Didem Pehlivanoglu, et al. · Psychoneuroendocrinology · 9
2023 · Javier A Tamargo, Larissa J Strath, et al. · Public Health Nutrition · 25
2023 · Natalie C. Ebner, Marilyn Horta, et al. · Current Opinion in Psychology · 14
2023 · Pedro A. Valdes-Hernandez, Chavier Laffitte Nodarse, et al. · Brain Research Bulletin · 14
2023 · Pedro A. Valdes-Hernandez, Alisa J. Johnson, et al. · Journal of Pain · 10
2023 · Pedro A. Valdes-Hernandez, Chavier Laffitte Nodarse, et al. · Scientific Reports · 16
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