Beta Cell Intracellular Calcium and Diabetes
Description: The prevalence of diabetes is dramatically increasing, affecting more than 7.5 billion people worldwide, with a significant economic burden, quantified in >$327 billion/year only in the United States, where 1 out of 3 adults has prediabetes. This is the first investigation into the mechanistic role of a major intracellular calcium release channel within the pancreatic beta cell in the pathogenesis of diabetes, using a novel and specific murine model. Our studies, relevant to public health and to the NIH mission to discover basic mechanisms underlying human disease, suggest an unprecedented role for this channel in the pathophysiology of diabetes via a pathway that involves the regulation of mitochondrial quality control.
Funding type: research
Funder scheme: R01
Start date: 2020-01-01
End date: 2024-11-30
Investigator: GAETANO SANTULLI
Institution: ALBERT EINSTEIN COLLEGE OF MEDICINE
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 197
Funder award ID: R01DK123259
OpenAlex ID: G1926672017