Targeting Cell-Type Specific Disease Phenotypes to Promote CNS Repair
Description: PROJECT NARRATIVE A major impediment to developing effective therapeutics after spinal cord injury and other neurological disorders is that therapeutics that target one cell type may be contraindicated for another cell type, thereby masking any potential beneficial effects. In this proposal, we will address this issue by utilizing single-cell transcriptomics and proteomics data of the spinal cord injury site to bioinformatically identify compounds that are predicted to reverse the disease phenotype in a cell-type and cell-state-specific manner. These compounds will be targeted to specific cell types using nanoparticle-based drug delivery systems that minimize off-target effects.
Funding type: research
Funder scheme: RM1
Start date: 2023-08-01
End date: 2028-04-30
Investigator: NAGI G AYAD
Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
Funded outputs count: 26
Funder award ID: RM1NS133003
OpenAlex ID: G9000893918