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Genetic Studies of Sarcomere-based Cardiac Diseases

Description: Project Narrative This proposal aims to leverage the efficient zebrafish model to understand why only some truncational mutations in TTN lead to cardiomyopathy, and which signaling pathways are involved in its pathogenesis that can be manipulated for therapeutic benefits.
Funding type: research
Funder scheme: R01
Start date: 2005-08-01
End date: 2027-06-30
Investigator: XIAOLEI XU
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 57
Funder award ID: R01HL081753
OpenAlex ID: G9000859962
Inhibition, But Not Depletion, of Erk Signaling Ameliorates Anthracycline-Induced Cardiotoxicity in Zebrafish
2025 · Maryam Moossavi, Ping Zhu, et al. · JACC CardioOncology · 2
An mTOR ‐Tfeb‐Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging
2025 · Yonghe Ding, Xueling Ma, et al. · Aging Cell · 3
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Deregulated nutrient response in ttntv cardiomyopathy can be repaired via Erk inhibition for cardioprotective effects
2025 · Feixiang Yan, Weiyue Wang, et al. · Journal of Molecular and Cellular Cardiology
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Nothobranchius furzeri: a vertebrate model for studying cardiac aging and cellular senescence
2025 · Xueling Ma, Yonghe Ding, et al. · npj Aging · 12
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An Intraperitoneal Injection Technique in Adult Zebrafish that Minimizes Body Damage and Associated Mortality
2024 · Maryam Moossavi, Hong Zhang, et al. · Journal of Visualized Experiments · 7
Allelic heterogeneity of TTNtv dilated cardiomyopathy can be modeled in adult zebrafish
2024 · Ping Zhu, Jiarong Li, et al. · JCI Insight · 5
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Assessing Cardiac Functions of Zebrafish from Echocardiography Using Deep Learning
2023 · Mao-Hsiang Huang, Amir Mohammad Naderi, et al. · Information · 5
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Molecular mechanisms of anthracycline induced cardiotoxicity: Zebrafish come into play
2023 · Maryam Moossavi, Xiaoguang Lu, et al. · Frontiers in Cardiovascular Medicine · 4
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Transcriptome studies of inherited dilated cardiomyopathies
2023 · Matthew Koslow, David Mondaca-Ruff, et al. · Mammalian Genome · 7
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Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy
2022 · Yonghe Ding, Mingmin Wang, et al. · Disease Models & Mechanisms · 21
Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish
2021 · Haisong Bu, Yonghe Ding, et al. · JCI Insight · 40
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A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies
2021 · Tai Le, Jimmy Zhang, et al. · Biosensors and Bioelectronics · 18
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2
2021 · Ling-Ling Qian, Xiaojing Sun, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 15
atg7 -Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
2021 · Yong Wang, Xiaoguang Lu, et al. · Circulation Research · 103
A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening
2021 · Tai Le, Jimmy Zhang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos
2021 · Amir Mohammad Naderi, Haisong Bu, et al. · Computers in Biology and Medicine · 26
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TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy
2021 · Maengjo Kim, Linghui Lu, et al. · International Journal of Molecular Sciences · 32
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A Swimming-based Assay to Determine the Exercise Capacity of Adult Zebrafish Cardiomyopathy Models
2021 · Xiao Ma, Xiaolei Xu · BIO-PROTOCOL · 5
Modeling Inherited Cardiomyopathies in Adult Zebrafish for Precision Medicine
2020 · Yonghe Ding, Haisong Bu, et al. · Frontiers in Physiology · 21
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Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy
2020 · Yonghe Ding, Jingchun Yang, et al. · Journal of the American Heart Association · 39
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Building the vertebrate codex using the gene breaking protein trap library
2020 · Noriko Ichino, MaKayla R Serres, et al. · eLife · 15
Aging-associated sinus arrest and sick sinus syndrome in adult zebrafish
2020 · Jianhua Yan, Hongsong Li, et al. · PLoS ONE · 24
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Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
2020 · Xiao Ma, Ping Zhu, et al. · Science Advances · 32
Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
2019 · Yonghe Ding, Alexey V. Dvornikov, et al. · Disease Models & Mechanisms · 26
Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy
2019 · Alexey V. Dvornikov, Mingmin Wang, et al. · Journal of Molecular and Cellular Cardiology · 36
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