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Perimenopause in Brain Aging and Alzheimer's Disease

Description: Narrative Worldwide women have a 2-fold greater risk for developing Alzheimer’s disease. The mission of the Perimenopause in Brain Aging and Alzheimer’s Disease Program Project is to discover why women are at greater risk for Alzheimer’s and based on that knowledge, create therapeutic strategies to prevent or delay development of Alzheimer’s disease. Further, our strategy provides a platform for a precision medicine approach to treating Alzheimer’s in both women and men.

Funder: National Institute on Aging

Funding type: program

Funder scheme: P01

Start date: 2006-08-15

End date: 2027-05-31

Investigator: ROBERTA EILEEN BRINTON

Institution: UNIVERSITY OF ARIZONA

Funded outputs count: 232

Funder award ID: P01AG026572

OpenAlex ID: G9000908146

Meta-analysis of glucose metabolism across Alzheimer’s, Parkinson’s and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures

2026 · Adam C. Raikes, Melissa Garza, et al. · Scientific Reports

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: implications for translational validity to the human

2026 · Adam C. Raikes, Avnish Bhattrai, et al. · Frontiers in Neuroscience · 2

Sex‐ and APOE ‐specific transcriptomic drug repurposing identifies four candidate therapeutics for Alzheimer's disease

2026 · Francesca Vitali, Adam C. Raikes, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 1

Humanized APP is the primary determinant of regional brain volume in humanized APOE knock‐in mice: a cross‐sectional ex vivo MRI study

2026 · Avnish Bhattrai, Adam C. Raikes, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling

2026 · Elsa M. Reyes-Reyes, Dhanalakshmi Chinnasamy, et al. · Frontiers in Immunology · 1

Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis

2026 · Simona Merlini, Roberto Gatta, et al. · Frontiers in Medicine

APOE4 accelerates menopause-associated brain metabolic shift and disrupts bioenergetic adaptation

2026 · Tian Wang, Yuan Shang, et al. · Frontiers in Aging Neuroscience · 1

Anti-inflammatory and immunomodulatory therapies are associated with reduced risk of age-associated neurodegenerative diseases: impact of sex and treatment duration

2026 · Helena Cortes-Flores, Georgina Torrandell-Haro, et al. · Frontiers in Aging Neuroscience

Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics

2026 · Lisa Mosconi, Matilde Nerattini, et al. · Scientific Reports · 1

Meta-analysis of glucose metabolism across Alzheimer’s, Parkinson’s and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures

2026 · Adam C. Raikes, Melissa Garza, et al. · medRxiv · 1

Corrigendum to “Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons” [Mol. Cell. Endocrinol. 384 1-2 (2014) 52-60]

2026 · Anusha Jayaraman, Christian J. Pike · Molecular and Cellular Endocrinology

HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling

2026 · EM Reyes-Reyes, D Chinnasamy, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Immunotherapies for risk reduction in age-associated neurodegenerative diseases: impact of sex and treatment duration

2026 · Helena Cortes-Flores, Georgina Torrandell-Haro, et al. · medRxiv · 1

White matter microstructural and macrostructural profiles during midlife reveal sex differences between men and women at different menopausal stages

2025 · Adam C. Raikes, Jonathan P. Dyke, et al. · Scientific Reports · 12

Aging shapes baseline immunity in sterilehoused female hAPOE mouse genotypes

2025 · Fernandez F, Reyes-Reyes E, et al. · Journal of Cellular and Molecular Immunology

Mitochondrial ROS sources steer neuroinflammation

2025 · Huajun Pan, Fei Yin · Nature Metabolism · 6

Carotid endarterectomy mitigates Alzheimer's disease and non–Alzheimer's disease dementia risk linked to asymptomatic carotid stenosis

2025 · Francesca Vitali, Georgina Torrandell‐Haro, et al. · Alzheimer s & Dementia · 8

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

2025 · Tian Wang, Zisu Mao, et al. · Frontiers in Aging Neuroscience · 11

Quantitative and simplified [18F] fluoroestradiol positron emission tomography (PET) measures of brain estrogen receptor expression

2025 · Matilde Nerattini, Valentina Berti, et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2

Multisystem failure, tipping points, and risk of Alzheimer's disease

2025 · Simona Merlini, Edward J. Bedrick, et al. · Alzheimer s & Dementia · 8

Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer’s risk population: A retrospective analysis

2025 · Francesca Vitali, Jean-Paul Wiegand, et al. · PLoS ONE · 2

Sex-specific associations of serum testosterone with gray matter volume and cerebral blood flow in midlife individuals at risk for Alzheimer’s disease

2025 · Matilde Nerattini, Schantel Williams, et al. · PLoS ONE · 10

Combination therapy targeting Alzheimer's disease risk factors is associated with a significant delay in Alzheimer's disease–related cognitive decline

2025 · Yuan Shang, Georgina Torrandell‐Haro, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 6

Effects of obesogenic diet and 17β-estradiol in female mice with APOE 3/3, 3/4, and 4/4 genotypes

2024 · Amy Christensen, Cassandra J. McGill, et al. · Frontiers in Aging Neuroscience · 8

Asymptomatic carotid artery stenosis is associated with increased Alzheimer’s disease and non-Alzheimer’s disease dementia risk

2024 · Francesca Vitali, Georgina Torrandell-Haro, et al. · Stroke and Vascular Neurology · 8