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Novel Mechanisms of Pesticide-Induced Neurotoxicity

Description: Narrative Chronic exposure to mitochondria-impairing neurotoxic pesticides is a major public health problem around the world and has been linked to many disease conditions including Parkinson’s disease. Despite the established link, the cellular and molecular mechanisms central to the role of mitochondria-impairing pesticide exposure in the pathogenesis of Parkinson’s disease remain unidentified. This proposal will systematically characterize the mechanisms of mitochondria-inhibiting neurotoxic pesticide-induced degeneration of nigrostriatal neurons using both neuronal cell culture and animal models to discern the role of the histone acetylation pathway in chronic pesticide exposure as it relates to the etiopathogenesis of Parkinson’s disease.

Funder: National Institute of Environmental Health Sciences

Funding type: research

Funder scheme: R01

Start date: 2017-04-01

End date: 2024-03-31

Investigator: ANUMANTHA GOUNDER KANTHASAMY

Institution: UNIVERSITY OF GEORGIA

Topic: Pesticide Exposure and Toxicity

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Funded outputs count: 34

Funder award ID: R01ES027245

OpenAlex ID: G2390928734