Regulation of the Autophagy Pathway with Age and in Long-lived Animals
Description: PROJECT NARRATIVE The US population of elderly people is rapidly growing and age-related diseases constitute a major health issue in our society; however, the cellular and molecular basis of aging and age-related disorders is poorly understood. This proposal aims to determine how autophagy – a cellular process of cytoplasmic degradation with major biological functions – modulates organismal aging. The proposed research has relevance to public health, because the mechanisms to be investigated are evolutionary conserved and the findings might ultimately provide therapies to treat aging-related diseases.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2011-08-15
End date: 2027-11-30
Investigator: MALENE HANSEN
Institution: BUCK INSTITUTE FOR RESEARCH ON AGING
Funded outputs count: 59
Funder award ID: R01AG038664
OpenAlex ID: G9000919401