Bladder Mucosal Dysfunction During Aging
Description: Narrative (Relevance) Lower urinary tract symptoms (LUTS) are major health related problems of the elderly and represent significant, and very costly health and quality of life problems of our society. In view of the complex control of the lower urinary tract, including anatomical, neurological and other mechanisms affected by aging- our team of collaborators is in a unique position (by virtue of extensive expertise and resources) to provide new insights into how aging alters mitochondrial dysfunction and oxidative stress that result in abnormal urodynamic behavior. These studies will provide a translational foundation for the development of new modalities targeting pathophysiological processes for the treatment of age-related bladder control problems.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2018-04-01
End date: 2026-03-31
Investigator: GERARD L APODACA
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 32
Funder award ID: R01AG056944
OpenAlex ID: G7407417088