Dysregulation of Naïve T cell Quiescence during Aging
Description: Project Narrative The breakdown of naïve T cell homeostasis is closely associated with increased susceptibility to infection during aging. However, very few strategies exist to study the mechanisms of long-term T cell maintenance in humans and particularly with age. The goal of this project is to utilize new single cell technologies to elucidate naïve T cell complexity and to develop novel methodologies to study age-related homeostatic decline, which will ultimately enhance immune protection against infections in older individuals.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K01
Start date: 2020-08-01
End date: 2025-05-31
Investigator: CLAIRE GUSTAFSON
Institution: ALLEN INSTITUTE
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 7
Funder award ID: K01AG068373
OpenAlex ID: G142783796