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Consequences of mtDNA damage to age-related degenerative processes

Description: PUBLIC HEALTH RELEVANCE: The role of mitochondrial DNA (mtDNA) damage to the aging process is poorly understood. This project will explore whether stem/progenitor cells pools are reduced when mtDNA is damaged. We will also study the molecular mechanisms involved. This reduction in stem/progenitor cells pools would lead to accelerated aging. In addition, we will develop a mouse model that accumulates mtDNA deletions with age. A better understanding of this process could lead to interventions to promote healthy aging.
Funding type: research
Funder scheme: R01
Start date: 2010-06-01
End date: 2021-12-31
Investigator: CARLOS TORRES MORAES
Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
Funded outputs count: 62
Funder award ID: R01AG036871
OpenAlex ID: G4143921164
Adult-Onset Deficiency of Mitochondrial Complex III in a Mouse Model of Alzheimer’s Disease Decreases Amyloid Beta Plaque Formation
2022 · Milena Pinto, Francisca Diaz, et al. · Molecular Neurobiology · 5
ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly
2021 · Tania Arguello, Susana Peralta, et al. · Cell Reports · 88
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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo
2021 · Ugne Zekonyte, Sandra R. Bacman, et al. · Nature Communications · 94
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Mild deficiency of mitochondrial Complex III in a mouse model of Alzheimer’s disease decreases amyloid beta plaque formation
2021 · milena pinto, Francisca Diaz, et al. · Research Square
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Metformin delays neurological symptom onset in a mouse model of neuronal complex I deficiency
2020 · Susana Peralta, Milena Pinto, et al. · JCI Insight · 21
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DNA‐editing enzymes as potential treatments for heteroplasmic mtDNA diseases
2020 · U. Zekonyte, S. R. Bacman, et al. · Journal of Internal Medicine · 29
Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches
2020 · Nadee Nissanka, Carlos T Moraes · EMBO Reports · 123
Myopathy reversion in mice after restauration of mitochondrial complex I
2020 · Claudia V Pereira, Susana Peralta, et al. · EMBO Molecular Medicine · 43
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Cybrid technology
2019 · Sandra R. Bacman, Nadee Nissanka, et al. · Methods in cell biology · 15
Sorting mtDNA Species—the Role of nDNA-mtDNA Co-evolution
2019 · Carlos T. Moraes · Cell Metabolism · 2
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Photobiomodulation enhancement of cell proliferation at 660 nm does not require cytochrome c oxidase
2019 · Paula L.V. Lima, Claudia V. Pereira, et al. · Journal of Photochemistry and Photobiology B Biology · 89
Mechanisms of Mitochondrial DNA Deletion Formation
2019 · Nadee Nissanka, Michal Minczuk, et al. · Trends in Genetics · 87
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation
2018 · Sandra R. Bacman, Johanna H. K. Kauppila, et al. · Nature Medicine · 271
Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis
2018 · Milena Pinto, Uma D. Vempati, et al. · Molecular Neurobiology · 12
Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes
2018 · Tania Arguello, Caroline Köhrer, et al. · Journal of Biological Chemistry · 24
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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
2018 · Claudia V Pereira, Sandra R Bacman, et al. · EMBO Molecular Medicine · 85
The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
2018 · Nadee Nissanka, Sandra R. Bacman, et al. · Nature Communications · 132
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ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels
2018 · Susana Peralta, Steffi Goffart, et al. · Journal of Cell Science · 110
Overexpression of PGC ‐1α in aging muscle enhances a subset of young‐like molecular patterns
2018 · Sofia Garcia, Nadee Nissanka, et al. · Aging Cell · 82
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Image-Based Analysis of Mitochondrial Area and Counting from Adult Mouse Dopaminergic Neurites
2018 · Nadee Nissanka, Carlos Moraes, et al. · BIO-PROTOCOL · 3
Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease
2017 · Nadee Nissanka, Carlos T. Moraes · FEBS Letters · 446
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Lack of Parkin Anticipates the Phenotype and Affects Mitochondrial Morphology and mtDNA Levels in a Mouse Model of Parkinson's Disease
2017 · Milena Pinto, Nadee Nissanka, et al. · Journal of Neuroscience · 69
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Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation
2017 · Pernille M. Madsen, Milena Pinto, et al. · Journal of Neuroscience · 52
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NO control of mitochondrial function in normal and transformed cells
2017 · Celia H. Tengan, Carlos T. Moraes · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 92
Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
2016 · Milena Pinto, Alicia M Pickrell, et al. · Cell Death and Differentiation · 55
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