Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site
Description: Non-alcoholic fatty liver disease and its more severe form, non-alcoholic steatohepatitis are now termed metabolic dysfunction-associated steatotic liver disease/steatohepatitis to focus on the underlying causal mechanisms. In this term-limited renewal, we will complete the ongoing prospective cohort studies (database) in children and adults (to define the natural course of NAFLD), and the vitamin E dosing study (VEDS) to identify the lowest effective therapeutic dose of vitamin E for NASH. Additionally, we will utilize existing multimodal data repositories to identify novel biomarkers and therapeutic targets for severity of NAFLD and sarcopenia using integrated multiomics analyses of clinical, genetic, transcriptomic, proteomic, histological, and imaging data.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2002-06-15
End date: 2027-06-30
Investigator: SRINIVASAN DASARATHY (lead)
Institutions: Cleveland Clinic Lerner College of Medicine, CLEVELAND CLINIC LERNER COM-CWRU
Funded outputs count: 281
Funder award ID: U01DK061732
OpenAlex ID: G9000904218