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Environmental, Genetic, and Epigenetic Mechanisms for Hormonal Change

Description: Project Narrative Puberty is a pivotal developmental period that has implications for physical and psychological health across the rest of the lifespan. Yet basic information regarding the hormonal, genetic, and epigenetic correlates of variability in the timing and pace of pubertal development is surprisingly sparse. This project will yield new discoveries on how environmental and genetic factors combine to shape pubertal development, and results will be useful to health researchers studying a variety of mental and physical illnesses that onset during puberty.
Funding type: research
Funder scheme: R01
Start date: 2019-07-18
End date: 2024-05-31
Investigator: KATHRYN PAIGE HARDEN
Institution: UNIVERSITY OF TEXAS AT AUSTIN
Field: Medicine
Funded outputs count: 49
Funder award ID: R01HD092548
OpenAlex ID: G2930976858
Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood
2026 · Laurel Raffington, Deniz Fraemke, et al. · Research Square
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Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway
2026 · Ole Røgeberg, Kathryn Paige Harden, et al. · Nature Communications
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In praise of scientific open relationships: Commentary on Caspi et al. (2026).
2026 · K. Paige Harden · Journal of Psychopathology and Clinical Science
Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood
2026 · D. Fraemke, L. Paulus, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Genomic insights into substance use and disinhibitory disorders
2026 · Camille M. Williams, Holly E. Poore, et al. · medRxiv · 1
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Salivary DNA methylation and pubertal development in adolescents
2025 · Abby J. deSteiguer, Trey Smith, et al. · Scientific Reports · 3
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Polygenic Associations With Educational Attainment in East Versus West Germany: Differences Emerge After Reunification
2025 · Deniz Fraemke, Yayouk E. Willems, et al. · Psychological Science · 4
Stability of Aging- and Cognition-Related Methylation Profile Scores Across Two Waves in Children and Adolescents
2025 · Abby J deSteiguer, Laurel Raffington, et al. · Child Development · 9
Do Polygenic Indices Capture “Direct” Effects on Child Externalizing Behavior Problems? Within-Family Analyses in Two Longitudinal Birth Cohorts
2024 · Peter T. Tanksley, Sarah J. Brislin, et al. · Clinical Psychological Science · 14
Differences in polygenic associations with educational attainment between West and East Germany before and after reunification
2024 · D. Fraemke, Y.E. Willems, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
2024 · Y. E. Willems, A. deSteiguer, et al. · Clinical Epigenetics · 11
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More than nature and nurture, indirect genetic effects on children’s academic achievement are consequences of dynastic social processes
2024 · Michel G. Nivard, Daniel W. Belsky, et al. · Nature Human Behaviour · 65
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Cohort profile: Genetic data in the German Socio-Economic Panel Innovation Sample (SOEP-G)
2023 · Philipp D. Koellinger, Aysu Okbay, et al. · PLoS ONE · 21
Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents
2023 · Abby J. deSteiguer, Laurel Raffington, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7
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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics
2023 · Camille M. Williams, Holly Poore, et al. · Behavior Genetics · 16
Salivary Epigenetic Measures of Body Mass Index and Social Determinants of Health Across Childhood and Adolescence
2023 · Laurel Raffington, Lisa Schneper, et al. · Archives of Pediatrics and Adolescent Medicine · 23
Associations of DNA-Methylation Measures of Biological Aging With Social Disparities in Child and Adolescent Mental Health
2023 · Laurel Raffington, Peter T. Tanksley, et al. · Clinical Psychological Science · 24
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Do polygenic indices capture “direct” effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts
2023 · Peter T. Tanksley, Sarah J. Brislin, et al. · medRxiv · 5
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Associations of socioeconomic disparities with buccal DNA-methylation measures of biological aging
2023 · L. Raffington, T. Schwaba, et al. · Clinical Epigenetics · 33
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Measuring the long arm of childhood in real-time: Epigenetic predictors of BMI and social determinants of health across childhood and adolescence
2023 · Laurel Raffington, Lisa Schneper, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Associations of Socioeconomic Disparities With Buccal DNA-Methylation Measures Of Biological Aging
2022 · L. Raffington, T. Schwaba, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 4
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Socially Stratified Epigenetic Profiles Are Associated With Cognitive Functioning in Children and Adolescents
2022 · Laurel Raffington, Peter T. Tanksley, et al. · Psychological Science · 41
A Mixed‐Methods Approach to Refining and Measuring the Construct of Positive Risk‐Taking in Adolescence
2022 · Megan W. Patterson, Lilla Pivnick, et al. · Journal of Research on Adolescence · 17
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Genetic variance in conscientiousness relates to youth psychopathology beyond executive functions.
2022 · Allison N. Shields, Margherita Malanchini, et al. · Journal of Psychopathology and Clinical Science · 3
Genetic determinism, essentialism and reductionism: semantic clarity for contested science
2022 · K. Paige Harden · Nature Reviews Genetics · 79
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