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Dietary methionine and cancer

Description: Diet and nutrition can affect metabolic pathways and determine the requirements of cancer cell metabolism. This work explores a specific aspect of diet, dietary methionine, which we have shown to have anti-tumor properties and now we will explore the nature of its anti-cancer effects.
Funding type: research
Funder scheme: R01
Start date: 2015-08-14
End date: 2026-07-31
Investigator: JASON W. LOCASALE
Institution: DUKE UNIVERSITY
Subfield: Biotechnology
Funded outputs count: 89
Funder award ID: R01CA193256
OpenAlex ID: G6556921576
Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster
2026 · Fangchao Wei, Shiyu Liu, et al. · Aging Cell
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function
2024 · Manojit M. Swamynathan, Shan Kuang, et al. · Science · 63
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Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
2024 · Deguan Lv, Deobrat Dixit, et al. · Cell Metabolism · 37
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo
2024 · Rutulkumar Patel, Daniel E. Cooper, et al. · Communications Biology · 13
Quantification of metabolic activity from isotope tracing data using automated methodology
2024 · Shiyu Liu, Xiaojing Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
2024 · Andrew J. Monteith, Haley E. Ramsey, et al. · Cancer Research · 14
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Methionine availability influences essential H3K36me3 dynamics during cell differentiation
2023 · Yudong Sun, Vijyendra Ramesh, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Methionine restriction and antitumor immunity
2023 · Fangchao Wei, Jason W. Locasale · Trends in cancer · 17
Uncoupling of lifespan and reproductive tradeoffs by dietary methionine and one-carbon metabolism
2023 · Fangchao Wei, Shiyu Liu, et al. · Research Square
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Nucleotide metabolism is linked to cysteine availability
2023 · Annamarie E. Allen, Yudong Sun, et al. · Journal of Biological Chemistry · 10
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Amino acid variability, tradeoffs and optimality in human diet
2022 · Ziwei Dai, Weiyan Zheng, et al. · Nature Communications · 59
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Diet and Exercise in Cancer Metabolism
2022 · Jason W. Locasale · Cancer Discovery · 29
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
2022 · Xin Gu, Patrick Jouandin, et al. · Nature · 59
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Predictive targeting of mitochondrial metabolism in Acute Myeloid Leukemia patients with a lipoic acid analog
2021 · Michael A. Reid, Shree Bose, et al. · medRxiv · 1
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Metabolomics in cancer research and emerging applications in clinical oncology
2021 · Daniel R. Schmidt, Rutulkumar Patel, et al. · CA A Cancer Journal for Clinicians · 649
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Epigenomic links from metabolism—methionine and chromatin architecture
2021 · Zhengtao Xiao, Jason W. Locasale · Current Opinion in Chemical Biology · 13
Metabolomics: insights into plant‐based diets
2021 · Annamarie E Allen, Jason W Locasale · EMBO Molecular Medicine · 8
Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine
2021 · Yudong Sun, Jason W. Locasale · Cell Stress · 25
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The Molecular Link from Diet to Cancer Cell Metabolism
2020 · Shree Bose, Annamarie E. Allen, et al. · Molecular Cell · 14
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Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle
2020 · Shiyu Liu, Ziwei Dai, et al. · Cell Metabolism · 61
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The evolving metabolic landscape of chromatin biology and epigenetics
2020 · Ziwei Dai, Vijyendra Ramesh, et al. · Nature Reviews Genetics · 498
The Molecular Link from Diet to Cancer Cell Metabolism
2020 · Shree Bose, Annamarie E. Allen, et al. · Molecular Cell · 91
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Cooperative virus propagation in COVID-19 transmission
2020 · Ziwei Dai, Jason W. Locasale · medRxiv · 4
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NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
2020 · Douglas B. Fox, Nina Marie G. Garcia, et al. · Nature Metabolism · 216
The Na + /K + ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors
2020 · Sydney M. Sanderson, Zhengtao Xiao, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 8
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