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HIV Infection and Latency In Astrocytes

Description: PROJECT NARRATIVE HIV-1 infection and abuse of drugs such as cocaine often cause a number of brain diseases and affect the ability of people to care for themselves and thus the quality of their daily life. The social and economic impact cannot be overemphasized. The current study seeks to have a better understanding of how HIV and drug abuse interact in the era of combination antiviral therapy and then use the knowledge acquired to develop new markers to monitor the disease progression and treatment response and develop new therapeutics.
Funding type: research
Funder scheme: R01
Start date: 2016-09-01
End date: 2022-07-31
Investigator: JOHNNY J HE
Institution: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
Subfield: Virology
Funded outputs count: 27
Funder award ID: R01DA043162
OpenAlex ID: G7139321677
Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability
2024 · Sahar Rezaei, Khalid A. Timani, et al. · Frontiers in Cellular and Infection Microbiology · 2
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Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter
2023 · Sahar Rezaei, Khalid A Timani, et al. · Aging and Disease · 9
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Metformin Treatment Leads to Increased HIV Transcription and Gene Expression Though Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter
2023 · Sahar Rezaei, Khalid A Timani, et al. · Preprints.org · 1
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HIV Tat Expression and Cocaine Exposure Lead to Sex- and Age-Specific Changes of the Microbiota Composition in the Gut
2023 · Lu Li, Xiaojie Zhao, et al. · Microorganisms · 3
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HIV Nef Expression Down-modulated GFAP Expression and Altered Glutamate Uptake and Release and Proliferation in Astrocytes
2022 · Kelly M. Wilson, Johnny J. He · Aging and Disease · 17
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Nef inhibits HIV transcription and gene expression in astrocytes and HIV transmission from astrocytes to CD4+ T cells
2022 · Suresh R. Kandel, Xiaoyu Luo, et al. · Journal of NeuroVirology · 5
HIV Tat and cocaine interactively alter genome-wide DNA methylation and gene expression and exacerbate learning and memory impairments
2022 · Xiaojie Zhao, Fan Zhang, et al. · Cell Reports · 16
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Cocaine exacerbates neurological impairments and neuropathologies in the iTat model of HIV-associated neurocognitive disorder through genome-wide alterations of DNA methylation and gene expression
2021 · Xiaojie Zhao, Fan Zhang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology
2021 · Xiaojie Zhao, Kelly Wilson, et al. · Brain · 25
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Unraveling neuroHIV in the Presence of Substance Use Disorders
2020 · Yu Lin, Johnny J. He, et al. · Journal of Neuroimmune Pharmacology · 4
Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies
2020 · Linda Chang, Huajun Liang, et al. · Journal of Neuroimmune Pharmacology · 22
Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging
2020 · Zhao Xiaojie, Fan Yan, et al. · Aging and Disease · 43
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Correction to: Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression
2019 · Ying Liu, Yinghua Niu, et al. · Journal of NeuroVirology · 1
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Tat expression led to increased histone 3 tri-methylation at lysine 27 and contributed to HIV latency in astrocytes through regulation of MeCP2 and Ezh2 expression
2019 · Ying Liu, Yinghua Niu, et al. · Journal of NeuroVirology · 8
Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model
2017 · Dianne Langford, Byung oh Kim, et al. · Journal of NeuroVirology · 38
RETRACTED ARTICLE: The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration
2017 · Jerel A. Fields, Jeff Metcalf, et al. · Journal of NeuroVirology · 18
HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway
2016 · Yan Fan, Xiang Gao, et al. · Journal of Neuroscience · 50
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HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression
2016 · Pejman Rahimian, Johnny J. He · Journal of Neuroinflammation · 54
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HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity
2016 · Yan Fan, Johnny J. He · Journal of Biological Chemistry · 45
HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation
2016 · Yan Fan, Johnny J. He · Journal of Biological Chemistry · 75
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Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation
2016 · Dohun Pyeon, Khalid Amine Timani, et al. · Virus Research · 17
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Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein
2016 · Pejman Rahimian, Johnny J. He · Journal of NeuroVirology · 71
HIV/neuroAIDS biomarkers
2016 · Pejman Rahimian, Johnny J. He · Progress in Neurobiology · 38
Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes
2014 · Xiaoyu Luo, Johnny J. He · Journal of NeuroVirology · 53
Involvement of miR-196a in HIV-associated neurocognitive disorders
2014 · Asen Bagashev, Ruma Mukerjee, et al. · APOPTOSIS · 16
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