Cerebromicrovascular rejuvenation by heterochronic blood exchange
Description: NARRATIVE The human brain is supplied by a dense array of vessels where each neuron has its supplying capillary. Aging impairs functionally and structurally the cerebromicrovasculature and thus induces consequential neuronal dysfunction and cognitive impairment. Our recent studies using heterochronic blood exchange (HBE) in mice showed that young blood rescues the age-related decline in signaling via the NAD+/SIRT1 axis and reverses circulating IGF-1 deficiency, each of which can result in vascular mitochondrial rejuvenation, attenuation of endothelial oxidative stress, improved endothelial vasodilator function and restoration of endothelial angiogenic processes, improving brain health.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2021-06-01
End date: 2024-05-31
Investigator: ANNA CSISZAR
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 86
Funder award ID: RF1AG072295
OpenAlex ID: G2787306855