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Age-related vascular cognitive impairment: role of endothelial senescence

Description: NARRATIVE The human brain is supplied by 600 km of vessels where each neuron has its supplying microvessel. Aging impairs functionally and structurally the cerebromicrovasculature and thus induces consequential neuronal dysfunction and cognitive impairment. Endothelial senescence, as a damage response in aging, might contribute to impaired cerebral microvascular function and structure and by selective elimination of senescent cells offers new targets for prevention and treatment of age-related cognitive impairment.
Funding type: research
Funder scheme: R01
Start date: 2020-08-01
End date: 2025-07-31
Investigator: ANNA CSISZAR
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Subfield: Physiology
Field: Medicine
Funded outputs count: 107
Funder award ID: R01AG068295
OpenAlex ID: G5671976326
Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging
2026 · Stefano Tarantini, Madison Milan, et al. · Research Square
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Rethinking dietary fat for the aging brain: the roles or ketosis and fat quality in cerebrovascular aging and VCID
2026 · Sharon Negri, Madison Milan, et al. · Critical Reviews in Food Science and Nutrition
Long-term cerebrovascular effects of cyclophosphamide and vincristine: endothelial senescence, impaired DNA repair signaling, and blood–brain barrier dysfunction
2026 · Dorina Nagy, Kiana Vali Kordestan, et al. · GeroScience · 1
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Circulating factors as modifiable therapeutic targets in brain and cerebrovascular aging: Insights from heterochronic parabiosis
2026 · Rafal Gulej, Dorina Nagy, et al. · Advances in Translational Research · 5
LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia
2026 · Jennifer Ihuoma, Madison Milan, et al. · Redox Biology · 13
Rejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery
2026 · Santny Shanmugarama, Till Gronemann, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Age-Related Alterations of Cerebral Autoregulation
2025 · Anna Ungvari, Attila Kállai, et al. · Life · 14
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Irradiation-induced brain senescence accelerates cardiac aging via systemic mechanisms: insights from transcriptomic profiling
2025 · Rafal Gulej, Roland Patai, et al. · GeroScience · 2
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Endothelial-to-mesenchymal transition in the central nervous system: A potential therapeutic target to combat age-related vascular fragility
2025 · Michaela L. Vance, Dorina Nagy, et al. · Journal of Pharmacology and Experimental Therapeutics · 5
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Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries
2025 · Sharon Negri, FENG YAN, et al.
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Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries
2025 · Sharon Negri, FENG YAN, et al.
PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience
2025 · Zoltan Ungvari, Otília Menyhart, et al. · GeroScience · 11
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Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments
2025 · Rafal Gulej, Roland Patai, et al. · GeroScience · 28
Effects of NAD+ supplementation with oral nicotinamide riboside on vascular health and cognitive function in older adults with peripheral artery disease: Results from a pilot 4-week open-label clinical trial
2025 · Zsofia Szarvas, Zeke A. Reyff, et al. · Journal of Pharmacology and Experimental Therapeutics · 18
Global and tissue-specific transcriptomic dysregulation in human aging: Pathways and predictive biomarkers
2025 · Muhammad Arif, Andrea Lehoczki, et al. · GeroScience · 9
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Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 56
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Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)
2025 · Attila Kallai, Anna Ungvari, et al. · GeroScience · 14
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Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 33
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Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 56
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Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia
2025 · Adam Nyul-Toth, Santny Shanmugarama, et al. · GeroScience · 10
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Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening
2025 · Roland Patai, Krish Patel, et al. · GeroScience · 15
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Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice
2025 · Boglarka Csik, Ádám Nyúl‐Tóth, et al. · Aging Cell · 44
Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain
2025 · Siva Sai Chandragiri, Adam Nyul-Toth, et al. · GeroScience · 8
Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?
2025 · Anna Ungvari, Ádám Nyúl-Tóth, et al. · GeroScience · 24
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity
2025 · Partha Mukhopadhyay, Burhan Yokus, et al. · GeroScience · 16
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