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SIRT1 as a regulator of health and lifespan of mammals

Funding type: research
Funder scheme: R37
Start date: 2007-04-01
End date: 2023-02-28
Investigator: DAVID A. SINCLAIR
Institution: HARVARD MEDICAL SCHOOL
Funded outputs count: 117
Funder award ID: R37AG028730
OpenAlex ID: G3213623957
Response to: The information theory of aging has not been tested
2024 · Jae-Hyun Yang, Motoshi Hayano, et al. · Cell · 6
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Loss of epigenetic information as a cause of mammalian aging
2023 · Jae-Hyun Yang, Motoshi Hayano, et al. · Cell · 643
Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
2022 · Angela H. Guo, Rachael Baliira, et al. · Scientific Reports · 32
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Applying the AFRAID and FRIGHT Clocks to Novel Preclinical Mouse Models of Polypharmacy
2022 · John Mach, Alice E Kane, et al. · The Journals of Gerontology Series A · 7
Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice
2021 · Shanlin Ke, Sarah J. Mitchell, et al. · Nutrients · 26
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Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.
2021 · Malcolm Maden · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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ARDD 2020: from aging mechanisms to interventions
2020 · Garik V. Mkrtchyan, Kotb Abdelmohsen, et al. · Aging · 58
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
2020 · Xiaohong Chen, João A. Amorim, et al. · Aging · 47
Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.
2020 · Pinghua Liu · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Reprogramming to recover youthful epigenetic information and restore vision
2020 · Yuancheng Lu, Benedikt Brommer, et al. · Nature · 820
Age and life expectancy clocks based on machine learning analysis of mouse frailty
2020 · Michael B. Schultz, Alice E. Kane, et al. · Nature Communications · 132
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Why does COVID-19 disproportionately affect older people?
2020 · Amber L. Mueller, Maeve S. McNamara, et al. · Aging · 1,128
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Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers
2020 · Golam M. Uddin, Neil A. Youngson, et al. · Cells · 32
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NAD+ Repletion Rescues Female Fertility during Reproductive Aging
2020 · Michael J. Bertoldo, Dave R. Listijono, et al. · Cell Reports · 326
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Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage
2019 · Emma Bolderson, Joshua T. Burgess, et al. · Nature Communications · 61
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DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging
2019 · Motoshi Hayano, Jae-Hyun Yang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 24
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NAD+ in Brain Aging and Neurodegenerative Disorders
2019 · Sofie Lautrup, David A. Sinclair, et al. · Cell Metabolism · 788
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Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice
2019 · Jaime M. Ross, Giuseppe Coppotelli, et al. · Aging Cell · 41
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Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research
2019 · Monty Montano, Shalender Bhasin, et al. · AIDS Research and Human Retroviruses · 14
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
2019 · Carlos Marques Palmeira, João Soeiro Teodoro, et al. · Free Radical Biology and Medicine · 161
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice
2019 · Neil A Youngson, G Mezbah Uddin, et al. · Reproduction · 38
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Frailty biomarkers in humans and rodents: Current approaches and future advances
2019 · Alice E. Kane, David A. Sinclair · Mechanisms of Ageing and Development · 101
Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
2019 · Stefano Tarantini, Marta Noa Valcarcel-Ares, et al. · Redox Biology · 285
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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
2019 · Hisayuki Amano, Arindam Chaudhury, et al. · Cell Metabolism · 182
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Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1
2019 · Jessica Feng, Avery LaChance, et al. · BMJ Case Reports · 3
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