Discovering the molecular mechanisms that determine replicative lifespan
Description: NARRATIVE Despite the fundamental importance of the replicative aging process, there are still huge gaps in our knowledge of the biological changes that cause aging and the molecular basis of these changes. Understanding the molecular causes of aging will better position us to intelligently design therapeutic interventions to delay these events, in order to extend lifespan. The proposed studies will fill these knowledge gaps by uncovering the molecular events that occur during amino acid depletion to influence lifespan, and will leverage these discoveries to identify targeted therapies to extend lifespan.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2017-09-30
End date: 2022-05-31
Investigator: JESSICA K TYLER
Institution: WEILL MEDICAL COLL OF CORNELL UNIV
Subfield: Aging
Domain: Life Sciences
Funded outputs count: 7
Funder award ID: R01AG050660
OpenAlex ID: G6005447278