Regulation of tumor recurrence by stress activated neutrophils
Description: Narrative Tumor recurrence is one of the largest clinical challenges in cancer. It is widely accepted that small numbers of tumor cells persist in non-proliferating (dormant) state until cells re-enter the cell cycle, thus originating metastases. The elucidation of the mechanisms, by which tumor cells are reawakened from dormancy, is crucial to achieve eradication of lung cancer. This application will address this problem by studying specific mechanisms regulating dormancy by neutrophils, evaluate their clinical significance and potential therapeutic intervention.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2020-06-01
End date: 2026-01-31
Investigator: RUGANG ZHANG
Institution: UNIVERSITY OF TX MD ANDERSON CAN CTR
Funded outputs count: 34
Funder award ID: R01CA243142
OpenAlex ID: G9000872843