The NFkB System in Dendritic Cells
Description: Project Narrative When the differentiation pathway of dendritic cells (DCs) – key regulators of human immune responses – is misregulated, a number of human ailments such as myeloid proliferative disorders, cancers, or inflammatory disease may result. In this project we will examine – at single cell resolution – how the NFkappaB signaling system regulates proper phasing of proliferation and differentiation processes in two major DC lineages. The proposed studies involve novel animal, cell culture, and mathematical models and aim to understand the regulatory mechanisms that underlie two human diseases, acute myeloid leukemia (AML) and Langerhans Cell Histiocytosis (LCH).
Funding type: research
Funder scheme: R01
Start date: 2018-04-03
End date: 2024-03-31
Investigator: ALEXANDER HOFFMANN
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Funded outputs count: 28
Funder award ID: R01AI127867
OpenAlex ID: G6457714056