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Alzheimers Disease Patient Registry

Description: PROJECT NARRATIVE The Mayo Clinic Study of Aging (MCSA) is a population-based longitudinal project on aging and cognition in the community. The National Institute on Aging and the Alzheimer's Association have recently published a new research framework for Alzheimer's Disease. We will evaluate this framework using a general community sample from the MCSA.

Funder: National Institute on Aging

Funding type: cooperative_agreement

Funder scheme: U01

Start date: 1986-09-30

End date: 2026-06-30

Investigator: JONATHAN GRAFF-RADFORD

Institution: MAYO CLINIC ROCHESTER

Funded outputs count: 1,340

Funder award ID: U01AG006786

OpenAlex ID: G388381678

TailEnrich enables discovery of dysregulated genes through disease sample enrichment testing

2026 · Hongdong Li, Yuhe Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Validation of plasma biomarker immunoassay‐based models for predicting brain amyloid positivity in cognitively impaired individuals

2026 · Jeremy A. Syrjanen, Daniel J. Figdore, et al. · Alzheimer s & Dementia

White matter microstructure and hyperintensity burden in isolated REM sleep behavior disorder

2026 · Elijah Mak, Scott A Przybelski, et al. · Brain Communications

Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

2026 · Yuan Hou, Yichen Li, et al. · Nature Neuroscience

Temporal dysregulation of PPARG-PRKAG2 co-localization in gray matter: Implications for cognitive decline and intervention targets in type 2 diabetes

2026 · Shelli R. Kesler, Kimberly A. Lewis, et al. · Journal of Alzheimer s Disease

A model of brain function to predict tau across Alzheimer’s disease and related disorders

2026 · Nick Corriveau-Lecavalier, Gemeng Zhang, et al. · Nature Communications

Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers

2026 · Dror Shir, Alicia Algeciras-Schimnich, et al. · Neurology

CSF and plasma lipid profiling predicts risk of cognitive impairment in cognitively unimpaired older adults

2026 · Takahisa Kanekiyo, Launia J. White, et al. · Alzheimer s & Dementia

Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer’s disease PET imaging biomarkers

2026 · Nikki H. Stricker, Elizabeth A. Boots, et al. · medRxiv

Neurofibrillary tangle deposition in primary idiotypic isocortices using flortaucipir PET in histopathologically confirmed Alzheimer’s disease

2026 · Keith A. Josephs, Stephen D. Weigand, et al. · iScience

Association Between Large Language Model‐Derived Mobility Functional Status Assessment and Clinical Outcomes

2026 · Sandeep Pagali, Xingyi Liu, et al. · Journal of the American Geriatrics Society

Feasibility of remote self-administered cognitive assessment in an Alzheimer’s disease treatment clinic

2026 · Alyssa N. Kaser, John L. Stricker, et al. · medRxiv

Clinical pathways for cognitively unimpaired individuals with Alzheimer's disease neuropathological change

2026 · Jonathan Graff-Radford, Leah Karliner, et al. · The Lancet Neurology · 2

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

2026 · Madison M. Reeves, Anna Calliari, et al. · Alzheimer s & Dementia

Topological morphology descriptors reveal sex-dependent changes in microglial morphology across AD neuropathologic change

2026 · Hannah B. Haberecht, Josie L. Emery, et al. · Acta Neuropathologica Communications

NeuroMorph: A Unified Morphological Reference Space for Cross-Disease Brain Profiling

2026 · Connor Dalby, Austin Dibble, et al. · medRxiv · 2

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer’s disease

2026 · Madison M. Reeves, Sara Aviles Carpintero, et al. · Alzheimer s Research & Therapy

Eligibility for Anti-Amyloid Therapies in Patients With Biomarker-Confirmed Atypical Alzheimer Disease Phenotypes

2026 · Dror Shir, Nick Corriveau-Lecavalier, et al. · Neurology · 1

Norms for Automatic Estimation of White Matter Hyperintensities Burden: LST-AI Service in neuGRID

2026 · Alberto Boccali, Silvia De Francesco, et al. · Diagnostics

Optimized plasma p‐tau217 and p‐tau217/Aβ42 cutoffs enhance detection of pre‐clinical Alzheimer's disease across diverse participants

2026 · Yoav D Piura, Paula A Aduen, et al. · Alzheimer s & Dementia · 1

Automated PET tracer classification in multi-site, multi-cohort studies using deep learning

2026 · Robel K. Gebre, Robert I. Reid, et al. · EJNMMI Research

SIEVEseq: unified differential expression, variability, and skewness analyses using RNA-Seq data

2026 · Hongxiang Li, Tsung Fei Khang · DNA Research

Diffusion MRI Identifies a Prolonged Pre-WMH Phase in Cerebral Small Vessel Disease

2026 · Prashanthi Vemuri, Mingzhao Hu, et al. · Stroke · 1

The Promise and Peril of Alzheimer Disease Prevention

2026 · Joshua D. Grill, Jonathan Graff-Radford · Neurology

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression

2026 · Audrey Low, Jeffrey L. Gunter, et al. · Annals of Neurology