Cardiomyocyte mitochondria and mtROS in cardiac aging, hypertrophy and failure
Description: Project Narrative: This multidisciplinary proposal combines molecular, physiologic and proteomics approaches with biostatistical and bioinformatic analyses to provide an integrated assessment of in vivo cardiac function, mitochondrial energetics and changes in the mitochondrial proteome. Important insights will be gained from study of the mechanisms of cardioprotection conferred by mitochondrial targeted catalase and the ability of mitochondrially targeted antioxidant and protective drugs to provide similar cardioprotective effects.
Funding type: research
Funder scheme: R01
Start date: 2010-05-01
End date: 2014-04-30
Investigator: PETER S RABINOVITCH
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 24
Funder award ID: R01HL101186
OpenAlex ID: G3299263301