Influenza vaccine failure in adults over age 75: role of chronic CMV infection
Description: PUBLIC HEALTH RELEVANCE: Seasonal influenza causes significant morbidity and mortality each year for older Americans. Influenza vaccine failure is a big issue for adults over age 75 who need vaccine protection the most. We propose to investigate the role of chronic CMV infection as defined by cellular CMV DNA and its underlying humoral and T-cell mechanisms contributing to this vaccine failure. This project has broad clinical and research implications in immunity and health of older Americans.
Funding type: research
Funder scheme: R01
Start date: 2014-01-01
End date: 2019-12-31
Investigator: SEAN XIAO LENG
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 33
Funder award ID: R01AI108907
OpenAlex ID: G8964564674