Cell decision underlying B-cell immune responses
Description: A hallmark of the humoral immune response is a two phased antibody response, the first being rapid and providing for low affinity antibodies, and the second occurring with a week delay but providing high affinity antibodies. An appropriate balance of both phases of the response is critical for an effective immune response. In this project we will investigate how the molecular network governing the dynamics of NFκB activity controls effectiveness of humoral immunity by phasing the affinity, abundance and diversity of antibodies.
Funding type: research
Funder scheme: R01
Start date: 2018-02-01
End date: 2025-01-31
Investigator: ALEXANDER HOFFMANN
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 32
Funder award ID: R01AI132731
OpenAlex ID: G2546499507