A Bio-Inspired Artificial Transcription Factor for Regeneration of Functional Hair Cells
Description: PROJECT NARRATIVE Sensorineural hearing loss is major public health concern that results from hair cell loss in the cochlea. Development of nanoparticle-based synthetic transcription factors that promote transdifferentiation of cochlear supporting cells into functional hair cells can be used to alleviate hearing loss. Use of NanoScript will be the first step towards a hearing loss therapy and is relevant to the component of NIH’s mission to investigate how innovative technology can be safely translated for clinical use in treating human illness and disability.
Funding type: research
Funder scheme: R01
Start date: 2018-05-01
End date: 2025-04-30
Investigator: KELVIN Y. KWAN
Institution: RUTGERS, THE STATE UNIV OF N.J.
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 48
Funder award ID: R01DC016612
OpenAlex ID: G1878301611