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Investigating Gains in Neurocognition in an Intervention Trial of Exercise

Description: Narrative In this Phase III randomized clinical trial, we will examine the effects of aerobic exercise on cognitive and brain function in late adulthood. We will be collecting a battery of cognitive, neuroimaging, amyloid, psychosocial, physical function measures, and blood-based biomarkers to examine the outcomes and mechanisms of the intervention.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2016-09-15

End date: 2024-05-31

Investigator: JEFFREY MURRAY BURNS

Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

Funded outputs count: 72

Funder award ID: R01AG053952

OpenAlex ID: G5344274930

Biomarker Convert: a novel approach to transform plasma pTau217 results across immunoassay and mass spectrometry analytical platforms

2026 · Karen J. Quadrini, Jiri Aubrecht, et al. · medRxiv

Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults

2026 · Lu Wan, Chaeryon Kang, et al. · Alzheimer s & Dementia

Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer’s Disease and Vascular Dementia

2026 · Rushil Srirambhatla, Jacques-Yves Campion, et al. · medRxiv

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study

2026 · Miranda G. Chappel‐Farley, Kelsey R. Sewell, et al. · Alzheimer s & Dementia

Lifespan exposure to hormone therapies and structural brain morphometry in older women

2026 · Robyn A. Honea, Amber Watts, et al. · NeuroImage · 1

Physical activity, aerobic fitness, and AD blood biomarkers: The IGNITE study

2026 · Lauren E. Oberlin, Patricio Solis‐Urra, et al. · Alzheimer s & Dementia · 1

Sex as a moderator of the association between cardiorespiratory fitness and depressive symptoms in older adults

2026 · Cristina Molina-Hidalgo, Michelle A Villarroel, et al. · The Journals of Gerontology Series B

Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer’s disease

2026 · Yijun Chen, Xuemei Zeng, et al. · Nature Communications · 11

Brain Glutathione Levels Associate With Cognitive Performance in Older Adults

2026 · Phil Lee, Kirk I. Erickson, et al. · Journal of Neurochemistry · 6

Plasma p-tau212 identifies cognitively unimpaired individuals with emerging amyloid-β pathology

2025 · Przemysław R. Kac, Armand González-Escalante, et al. · Journal of Neurology · 3

Associations between white matter lesions, adiposity, and systemic inflammation in late adulthood: Results from the IGNITE study

2025 · Shivangi Jain, Patricio Solis-Urra, et al. · Brain Behavior and Immunity · 1

Association between 24‐h time‐use composition and brain age: The IGNITE study

2025 · Audrey M. Collins, Maddison L. Mellow, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 1

Multilevel and multidimensional features of socioeconomic status and cognitive function in older adulthood: a cross-sectional analysis of the IGNITE study

2025 · Jermon A. Drake, Lu Wan, et al. · The Lancet Regional Health - Americas · 6

Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

2025 · Joseph Therriault, Wagner S Brum, et al. · The Lancet Neurology · 100

Arterial stiffness moderates the link between NfL and cognition: The IGNITE study

2025 · Amani M. Norling, Lewis A. Lipsitz, et al. · Alzheimer s & Dementia · 7

Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease

2025 · Alexandra Gogola, Xuemei Zeng, et al. · Alzheimer s & Dementia · 7

Pittsburgh plasma p‐tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community

2025 · Anuradha Sehrawat, Xuemei Zeng, et al. · Alzheimer s & Dementia · 10

White matter microstructure mediates the association between cardiorespiratory fitness and cognitive performance in older adults

2025 · Emma M. Tinney, Aaron E. L. Warren, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 3

Corrigendum to “Where do plasma biomarkers fit in with current Alzheimer’s disease detection?” [volume 33, issue 4, April 2025, pages 428–437]

2025 · Ariel Gildengers, Andrea M. Weinstein, et al. · American Journal of Geriatric Psychiatry

Self-report and actigraphy measures of sleep and domain-specific cognitive performance in older adults

2025 · Kelsey R. Sewell, Audrey M. Collins, et al. · GeroScience · 5

Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study

2025 · Amber Watts, Shannon Donofry, et al. · Frontiers in Aging Neuroscience · 8

Plasma p‐tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease

2025 · Przemysław R. Kac, Daniel Alcolea, et al. · Alzheimer s & Dementia · 20

Physical activity may mitigate sleep‐related cognitive deficits in older adults: Findings from the IGNITE study

2025 · Kelsey R. Sewell, Audrey M. Collins, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 5

The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment

2025 · Ariel G. Gildengers, Tamer S. Ibrahim, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 6

24-Hour time use and cognitive performance in late adulthood: results from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study

2025 · Audrey M Collins, Maddison L Mellow, et al. · Age and Ageing · 14