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Emerging role of glymphatic clearance in Huntington's disease

Description: Huntington's disease (HD) is a neurodegenerative disorder that presents with progressive motor, psychiatric, and cognitive symptoms leading to early disability and mortality. No treatments to delay the onset or slow the disease progression exist yet. This project will provide fundamental insights into the role of the glymphatic system in HD and may reveal a mechanistic basis for identifying new therapeutics as well as potential biomarkers for HD.
Funding type: research
Funder scheme: R01
Start date: 2023-04-01
End date: 2028-03-31
Investigator: WENZHEN DUAN (lead)
Field: Medicine
Funded outputs count: 11
Funder award ID: R01NS127344
OpenAlex ID: G9000891251
Depletion of border-associated macrophages impairs CSF flow and exacerbates extranuclear mutant Huntingtin aggregation in the zQ175DN mouse model of Huntington’s disease
2026 · Yanli Jiang, Rahul Sondawle, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Restoring Aquaporin-4 alleviates molecular and motor phenotypes in zQ175 mouse model of Huntington’s disease
2026 · Hongshuai Liu, Zichen Ding, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Computer vision-aided locomotor behavioral analysis identifies therapeutic motor signatures in a mouse model of Huntington’s disease
2026 · Lida Du, Zhenyu Wang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Neurovascular and metabolic dysfunction with cell type-specific transcriptomic changes in presymptomatic 5XFAD mice
2026 · Minmin Yao, Na Sun, et al. · Fluids and Barriers of the CNS · 8
Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington's disease
2025 · Qian Wu, Minmin Yao, et al. · Experimental Neurology · 3
The glymphatic system in Huntington's disease
2025 · Wenzhen Duan, Yuan Zhou, et al. · Journal of Huntington s Disease · 8
Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation
2025 · Jayvik Joshi, Minmin Yao, et al. · Imaging Neuroscience · 7
Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model
2024 · Minmin Yao, Zhiliang Wei, et al. · Neurobiology of Disease · 38
Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z ‐spectroscopy ( UFZ ) MRI at 3T
2024 · Licheng Ju, Michael Schär, et al. · Magnetic Resonance in Medicine · 7
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Glymphatic influx and clearance are perturbed in Huntington’s disease
2024 · Hongshuai Liu, Lin Chen, et al. · JCI Insight · 36
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Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins
2023 · Zhiliang Wei, Hongshuai Liu, et al. · NeuroImage · 37