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Cell Autonomous and Non-Autonomous Mechanisms of Aging

Description: PUBLIC HEALTH RELEVANCE: In order to develop therapeutic strategies for delaying onset of age-related pathology, a better understanding of the underlying cause(s) of aging is required. The goal of this Program Project Grant is to identify key mechanisms driving aging and age-related pathologies through both cell autonomous and non-autonomous mechanisms using mouse models of accelerated and natural aging.
Funding type: program
Funder scheme: P01
Start date: 2013-07-15
End date: 2020-04-30
Investigator: PAUL D. ROBBINS
Institution: UNIVERSITY OF MINNESOTA
Subfield: Aging
Funded outputs count: 140
Funder award ID: P01AG043376
OpenAlex ID: G1835854503
Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan
2026 · Lei Justan Zhang, Rahagir Salekeen, et al. · Aging Cell
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Senotypes define the diverse landscape of senescent cells
2026 · Marissa J. Schafer, Nathan Basisty, et al. · Nature Aging · 2
Polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells
2026 · Lei Justan Zhang, Rahagir Salekeen, et al. · Cell Press Blue · 7
Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b
2026 · Peter G. Alexander, Bowen Yan, et al. · Aging · 1
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The Sixth Annual Symposium of the Midwest Aging Consortium
2025 · Ines Sturmlechner, Sarah A Ashiqueali, et al. · The Journals of Gerontology Series A
Space radiation induces distinct senescent phenotypes: Implications for space travel
2025 · Louise E. Pitcher, Bipasha Mukherjee, et al. · npj Aging · 4
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Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
2025 · Masayoshi Suda, Selim Chaib, et al. · Cell Metabolism · 23
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Targeting DNA damage in ageing: towards supercharging DNA repair
2025 · Arturo Bujarrabal-Dueso, George A. Garinis, et al. · Nature Reviews Drug Discovery · 29
Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair
2025 · Paul Robbins, Lei Zhang, et al. · Research Square · 5
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Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair
2025 · Lei Justan Zhang, Osama Elsallabi, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles
2025 · Tianpeng Zhang, Allancer D. C. Nunes, et al. · Aging Cell · 10
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Therapeutic application of extracellular vesicles in human diseases
2025 · Allancer Nunes, Tianpeng Zhang, et al. · Molecular Therapy · 14
The Fifth Annual Symposium of the Midwest Aging Consortium
2024 · Brenda F Reader, Lorena Rosas, et al. · The Journals of Gerontology Series A
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Identification of lipid senolytics targeting senescent cells through ferroptosis induction
2024 · Lei Justan Zhang, Rahagir Salekeen, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
Guidelines for minimal information on cellular senescence experimentation in vivo
2024 · Mikolaj Ogrodnik, Juan Carlos Acosta, et al. · Cell · 377
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Failure to Repair Endogenous DNA Damage in β-Cells Causes Adult-Onset Diabetes in Mice
2023 · Matthew J. Yousefzadeh, Ryan D. O’Kelly, et al. · 9
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Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities
2023 · Prashanta Silwal, Allison M. Nguyen-Thai, et al. · Biomolecules · 218
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Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy
2023 · Chathurika Henpita, Rajesh Vyas, et al. · Aging Cell · 28
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Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target
2022 · Akilavalli Narasimhan, Rafael R. Flores, et al. · Current Diabetes Reports · 38
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Cellular senescence: a key therapeutic target in aging and diseases
2022 · Lei Zhang, Louise E. Pitcher, et al. · Journal of Clinical Investigation · 632
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Immune Senescence, Immunosenescence and Aging
2022 · Kyoo-A Lee, Rafael R. Flores, et al. · Frontiers in Aging · 283
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Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
2022 · Lei Zhang, Louise E. Pitcher, et al. · FEBS Journal · 638
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes
2021 · Allancer D. C. Nunes, Moritz Weigl, et al. · GeroScience · 36
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
2021 · Lei Zhang, Jing Zhao, et al. · Aging Cell · 89
Recent advances in the discovery of senolytics
2021 · Lei Zhang, Louise E. Pitcher, et al. · Mechanisms of Ageing and Development · 115
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