Systems approaches to link tissue-specific expression to disease
Description: PUBLIC HEALTH RELEVANCE: The GTEx Project will examine patterns of gene expression across numerous tissues in a large number of human donors, and relate these patterns to the underlying DNA of these individuals. The results will be used to better determine how genes act to cause disease, by describing which underlying genetic variants cause variation in expression in the organs and tissues most relevant for various diseases. This application aims to provide the tools, analysis, and framework to identify which DNA variants affect the expression of genes in a manner that is common to many tissues, and which are specific to one or a few tissues. The results will be used to gain a better understanding of the complex patterns of DNA variation in causing complex disease.
Funding type: research
Funder scheme: R01
Start date: 2013-08-15
End date: 2017-06-30
Investigator: ANDREW B NOBEL
Institution: NORTH CAROLINA STATE UNIVERSITY RALEIGH
Funded outputs count: 139
Funder award ID: R01MH101819
OpenAlex ID: G4436194330