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Characterizing age-related decline of neural circuits by single-cell profiling

Description: Project Narrative Appropriate brain function depends on precise neural circuit assembly during development and on long- term maintenance of circuit integrity throughout the life. Employing single-cell genomic and epigenomic approaches, I propose to characterize cellular and molecular mechanisms underlying the developmental circuit assembly and age-induced circuit decline using the Drosophila olfactory system.
Funding type: research
Funder scheme: R00
Start date: 2019-04-01
End date: 2024-01-31
Investigator: HONGJIE LI
Institution: BAYLOR COLLEGE OF MEDICINE
Funded outputs count: 20
Funder award ID: R00AG062746
OpenAlex ID: G1177392526
Aging atlas reveals cell-type-specific effects of pro-longevity strategies
2024 · Shihong Max Gao, Yanyan Qi, et al. · Nature Aging · 39
Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing
2024 · Daniel C. Sutton, Jonathan C. Andrews, et al. · PLoS ONE · 1
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Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity
2023 · Nadja S Katheder, Kristen C Browder, et al. · eLife · 18
TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy
2023 · Baiping Wang, Heidi Martini-Stoica, et al. · Nature Neuroscience · 106
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Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg
2023 · Akira Mamiya, Anne Sustar, et al. · Neuron · 33
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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution
2023 · Tzu-Chiao Lu, Maria Brbić, et al. · Science · 118
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Aging Atlas Reveals Cell-Type-Specific Regulation of Pro-longevity Strategies
2023 · Shihong Max Gao, Yanyan Qi, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 14
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Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes
2023 · Amelie A. Raz, Gabriela S. Vida, et al. · eLife · 69
Diverse cell-specific patterns of alternative polyadenylation in Drosophila
2022 · Seungjae Lee, Yen-Chung Chen, et al. · Nature Communications · 28
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Non-canonical odor coding in the mosquito
2022 · Margaret Herre, Olivia V. Goldman, et al. · Cell · 189
Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing
2022 · Jun Xu, Yifang Liu, et al. · Proceedings of the National Academy of Sciences · 43
Isolation and RNA sequencing of single nuclei from Drosophila tissues
2022 · Colleen N. McLaughlin, Yanyan Qi, et al. · STAR Protocols · 36
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Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons
2022 · Darya Task, Chun-Chieh Lin, et al. · eLife · 141
Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
2022 · Hongjie Li, Jasper Janssens, et al. · Science · 847
A cell atlas of the fly kidney
2021 · Jun Xu, Yifang Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 6
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Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons.
2021 · Task, Darya, Lin, Chun-Chieh, et al. · Apollo (University of Cambridge) · 108
Gut cytokines modulate olfaction through metabolic reprogramming of glia
2021 · Xiaoyu Tracy Cai, Hongjie Li, et al. · Nature · 62
Chemoreceptor Co-Expression in Drosophila Olfactory Neurons
2020 · Darya Task, Chun-Chieh Lin, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 27
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Single‐cell RNA sequencing in Drosophila: Technologies and applications
2020 · Hongjie Li · Wiley Interdisciplinary Reviews Developmental Biology · 55
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