Memory T Cell Development and Survival in T Cell Responses of Older Individuals
Description: PROJECT NARRATIVE With increasing age, the ability of the immune system to fend off infectious organisms or to control chronic infections declines. Consequences include the age-dependent reactivation of zoster infections, the increased morbidity and mortality from influenza, and the reduced response to vaccinations. With the changing demographics of the US population, this age-related immune incompetence is a major health problem. This proposal will explore new pathways to improve the generation of immune memory after vaccination.
Funding type: research
Funder scheme: R01
Start date: 2017-04-01
End date: 2024-03-31
Investigator: JORG J GORONZY
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 86
Funder award ID: R01AI129191
OpenAlex ID: G7998460746