Targeting cellular senescence with oral fisetin supplementation to improve vascular aging
Description: PROJECT NARRATIVE The risk of developing cardiovascular diseases increases with aging largely due to declines in the function of arteries which are influenced by cellular senescence, a state of nearly irreversible cell cycle arrest. This study will investigate the potential of a novel, natural dietary supplement, fisetin, for treating age-related arterial dysfunction by suppressing cellular senescence. Overall, this research has the potential to identify a new therapeutic strategy – with great promise as a dietary supplement and for the translation to humans for treating and preventing age-related arterial dysfunction and thereby reducing risk of cardiovascular diseases.
Funding type: fellowship
Funder scheme: F31
Start date: 2022-08-19
End date: 2025-11-30
Investigator: SOPHIA ANDREA MAHONEY
Institution: UNIVERSITY OF COLORADO
Funded outputs count: 14
Funder award ID: F31HL165885
OpenAlex ID: G9000920127