Tissue senescence and age-associated metabolic dysfunction: the role of immune cell mediated inflammation
Description: Chronic low-grade inflammation, a hallmark of advancing age termed inflammaging, has been implicated in metabolic dysfunction. Increased senescent burden in both solid organs (i.e.; liver, adipose tissue) and immune cells, also known as immunosenescence, likely contribute to inflammaging, but the interplay between the two, the mechanisms governing these processes and how they lead to metabolic dysfunction are poorly understood. Here, we seek to elucidate whether cellular senescence per se, immune cell recruitment/accumulation and the associated tissue inflammation, or both underlie age-related metabolic dysfunction.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-03-15
End date: 2027-12-31
Investigator: LISA A LESNIEWSKI
Institution: UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
Funded outputs count: 18
Funder award ID: R01AG076748
OpenAlex ID: G9000920078