Cancer Therapy-induced Long-term Bone Marrow Injury
Description: PUBLIC HEALTH RELEVANCE: This project focuses on elucidating the fundamental molecular mechanisms by which ionizing radiation (IR) and chemotherapy induce long-term bone marrow (LT-BM) injury. The results of the proposed studies can lead to the development of more effective strategies to prevent and mitigate IR- and chemotherapy-induced LT-BM toxicity in cancer patients. Such strategies can significantly reduce the potentially life-threatening long-term effects of conventional cancer therapy on the hematopoietic system, increase the compliance of cancer patients to subsequent consolidation cancer treatments, and facilitate the long-term engraftment and recovery of hematopoietic function after autologous and allogeneic BM transplantation.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2007-07-01
End date: 2020-02-29
Investigator: DAOHONG ZHOU
Institution: UNIVERSITY OF FLORIDA
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Funded outputs count: 48
Funder award ID: R01CA122023
OpenAlex ID: G2567115643