Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's Disease
Description: Project Narrative - This proposal aims to develop novel molecular network based drug repositioning approaches to identify FDA approved drugs and their combinations that can potentially reverse molecular signatures and network states of Alzheimer's disease (AD) derived from large-scale bulk-tissue and single cell transcriptomic data in AD. A number of predicted drugs and drug combinations will be validated using multiple model systems including mouse primary brain cells, human iPSC derived brain cells and AD mouse models.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-09-15
End date: 2026-05-31
Investigator: KRISTEN JENNIFER BRENNAND
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 39
Funder award ID: R01AG068030
OpenAlex ID: G4777055882