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Regulation of macrophage metabolism in aged muscle during recovery

Description: Narrative Poor muscle recovery following disuse is frequent amongst older adults leading to low muscle mass, weakness and increased disability. We have proposed to test specific mechanisms of a disrupted macrophage metabolic state during recovery from disuse in aged mice and humans. These findings will produce new knowledge of macrophage metabolism that will aid in the development of therapeutic strategies to promote muscle recovery in aged individuals.
Funding type: research
Funder scheme: R01
Start date: 2022-05-15
End date: 2027-04-30
Investigator: MICAH J DRUMMOND
Institution: UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
Funded outputs count: 19
Funder award ID: R01AG076075
OpenAlex ID: G9000901077
2026 · Paul-Emile Bourrant, Elena M. Yee, et al. · Science Advances · 3
2026 · Evelyn Ocegueda, Gabrielle Chase, et al. · Aging Cell · 1
2025 · Edwin R. Miranda, Justin L. Shahtout, et al. · Free Radical Biology and Medicine
2025 · Precious C. Opurum, Stephen T. Decker, et al. · American Journal of Physiology-Renal Physiology · 3
2025 · Zachary J. Fennel, Ryan M. O’Connell, et al. · American Journal of Physiology-Endocrinology and Metabolism · 12
2024 · Piyarat Siripoksup, Guoshen Cao, et al. · Journal of Clinical Investigation · 25
2023 · Justin L. Shahtout, Hiroaki Eshima, et al. · Journal of Cachexia Sarcopenia and Muscle · 18
2023 · Jonathan J. Petrocelli, Jingtong Liu, et al. · American Journal of Physiology-Endocrinology and Metabolism · 10
2023 · Elena M. Yee, Carson T. Hauser, et al. · Frontiers in Physiology · 4
2023 · Emelia Zukowski, Marco Sannella, et al. · Aging Cell · 24
2023 · Patrick J. Ferrara, Paul T. Reidy, et al. · Journal of Applied Physiology · 12
2022 · Piyarat Siripoksup, Guoshen Cao, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
2022 · Patrick J. Ferrara, Elena M. Yee, et al. · Journal of Applied Physiology · 23
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