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DNA Repair and Mitochondrial Dysfunction in T Cell Aging

Description: The immune system changes profoundly with progressive age, leaving the elderly susceptible to cancer, infection and tissue inflammation. Immune aging occurs prematurely in patients with rheumatoid arthritis and is associated with defects in DNA repair and with reprogramming of cellular metabolism. Here, we study the role of mitochondria and of mitochondrial DNA repair in immune aging.
Funding type: research
Funder scheme: R01
Start date: 2013-12-20
End date: 2025-12-31
Investigator: CORNELIA M. WEYAND
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 170
Funder award ID: R01AI108906
OpenAlex ID: G2646670792
The immunology behind inflammaging—causes, sources, and mechanisms
2026 · Ines Sturmlechner, Nathan K. LeBrasseur, et al. · Journal of Allergy and Clinical Immunology · 3
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis
2026 · Tao Huang, Yoshinori Takashima, et al. · Immunity · 19
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation
2026 · Jitendra Kumar, Yoshinori Takashima, et al. · Cell Metabolism · 10
Antigen-specific T H 17 cells offset the age-related decline in durable T cell immunity
2026 · Ines Sturmlechner, Abhinav Jain, et al. · Science Advances · 5
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Immune Age, Cardiovascular Disease, and Anti-Viral Immunity
2025 · Kevin-Phu C. Le, Fahad Shuja, et al. · Cells · 1
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Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells
2025 · Ines Sturmlechner, Abhinav Jain, et al. · Nature Communications · 22
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Perivascular Tertiary Lymphoid Structures in Autoimmune Disease
2025 · Jörg J. Goronzy, Cornelia M. Weyand · Immunological Reviews · 9
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Antigen-specific Th17 T cells offset the age-related decline in durable T cell immunity
2025 · Ines Sturmlechner, Abhinav Jain, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Immune Aging in Rheumatoid Arthritis
2025 · Cornelia M. Weyand, Jörg J. Goronzy · Arthritis & Rheumatology · 52
Distinctive clinical features in biopsy-proven nerve large-arteriole vasculitis and microvasculitis
2024 · Pannathat Soontrapa, Marcus V Pinto, et al. · Brain · 6
Metabolic checkpoints in rheumatoid arthritis
2024 · Cornelia M. Weyand, Jörg J. Goronzy · Seminars in Arthritis and Rheumatism · 34
Subclinical aortic inflammation in patients with polymyalgia rheumatica
2024 · Mahmut S Kaymakci, Gerald J Berry, et al. · Lara D. Veeken · 5
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IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease
2024 · Qingxiang Liu, Yanyan Zheng, et al. · Journal of Clinical Investigation · 18
Immune checkpoints in autoimmune vasculitis
2024 · Yuki Sato, Maria Tada, et al. · Best Practice & Research Clinical Rheumatology · 6
PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age
2024 · Huimin Zhang, Hirohisa Okuyama, et al. · JCI Insight · 8
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Stem-like CD4 + T cells in perivascular tertiary lymphoid structures sustain autoimmune vasculitis
2023 · Yuki Sato, Abhinav Jain, et al. · Science Translational Medicine · 71
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Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis
2023 · Simon Parreau, Elsa Molina, et al. · Frontiers in Immunology · 17
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Heterogeneity of memory T cells in aging
2023 · Abhinav Jain, Ines Sturmlechner, et al. · Frontiers in Immunology · 33
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Persistent aortic inflammation in patients with giant cell arteritis
2023 · Mahmut S. Kaymakci, Nicholas A. Boire, et al. · Autoimmunity Reviews · 38
Immune aging – A mechanism in autoimmune disease
2023 · Yanyan Zheng, Qingxiang Liu, et al. · Seminars in Immunology · 102
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T cell fate decisions during memory cell generation with aging
2023 · Ines Sturmlechner, Abhinav Jain, et al. · Seminars in Immunology · 31
Relapse Risk and Safety of Long-Term Tocilizumab Use Among Patients With Giant Cell Arteritis: A Single-Enterprise Cohort Study
2023 · Matthew J. Samec, Jigisha Rakholiya, et al. · The Journal of Rheumatology · 35
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Generation and durability of immune memory in older adults
2023 · Hirohisa Okuyama, Cornelia M. Weyand, et al. · Journal of Allergy and Clinical Immunology · 5
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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging
2023 · Jun Jin, Yunmei Mu, et al. · Nature Aging · 65
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Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity
2023 · Kevin Y. Cunningham, Benjamin Hur, et al. · Scientific Reports · 20
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