Get started
Award

Anti-Angiogenic Mechanisms in Human Obesity

Description: PUBLIC HEALTH RELEVANCE: The number of obese Americans persists at record levels as 69% of the US population is currently overweight or obese. Cardiovascular disease is the main cause of death in this population and this project seeks to investigate clinically important mechanisms of obesity-related vascular and metabolic disease as an area of high priority research.
Funding type: research
Funder scheme: R01
Start date: 2014-11-14
End date: 2020-10-31
Investigator: NOYAN GOKCE
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Funded outputs count: 33
Funder award ID: R01HL126141
OpenAlex ID: G3792567197
Perivascular Adipose Tissue Inflammation in Ischemic Heart Disease
2021 · Celestina Mazzotta, Sanchita Basu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 49
PDF
Cardiovascular Disease, Aging, and Clonal Hematopoiesis
2019 · Megan A. Evans, Soichi Sano, et al. · Annual Review of Pathology Mechanisms of Disease · 163
PDF
Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload–Induced Cardiac Dysfunction
2019 · Ying Wang, Soichi Sano, et al. · Circulation · 88
Fat‐Specific Protein 27 Regulation of Vascular Function in Human Obesity
2019 · Shakun Karki, Melissa G. Farb, et al. · Journal of the American Heart Association · 7
Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity
2018 · Doan T. M. Ngo, Aaron L. Sverdlov, et al. · American Journal of Physiology-Endocrinology and Metabolism · 52
Clonal Hematopoiesis and Its Impact on Cardiovascular Disease
2018 · Soichi Sano, Ying Wang, et al. · Circulation Journal · 47
PDF
Relaxin Family Member Insulin‐Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models
2018 · Sonomi Maruyama, Chia‐Ling Wu, et al. · Journal of the American Heart Association · 20
Somatic Mutations and Clonal Hematopoiesis
2018 · José J. Fuster, Kenneth Walsh · Circulation Research · 163
PDF
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome
2018 · Soichi Sano, Kosei Oshima, et al. · Journal of the American College of Cardiology · 701
PDF
Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation
2017 · María A. Zuriaga, José J. Fuster, et al. · Scientific Reports · 50
PDF
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
2017 · Melissa G. Farb, Song-Young Park, et al. · Journal of Visualized Experiments · 4
Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis
2017 · Susan MacLauchlan, Maria A. Zuriaga, et al. · Arthritis Research & Therapy · 26
PDF
Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots
2017 · Maria A. Zuriaga, Jose J. Fuster, et al. · Frontiers in Cardiovascular Medicine · 122
PDF
WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans
2017 · Shakun Karki, Doan T. M. Ngo, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 36
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
2017 · José J. Fuster, Susan MacLauchlan, et al. · Science · 1,539
WNT5A-JNK regulation of vascular insulin resistance in human obesity
2016 · Melissa G Farb, Shakun Karki, et al. · Vascular Medicine · 42
Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture
2016 · Sonomi Maruyama, Kazuto Nakamura, et al. · EMBO Molecular Medicine · 112
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease
2016 · José J. Fuster, Noriyuki Ouchi, et al. · Circulation Research · 668
PDF
Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a–JNK Signaling
2016 · Rosa Bretón-Romero, Bihua Feng, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 116
PDF
Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and Protects the Heart from Ischemia/Reperfusion Injury
2015 · Kazuto Nakamura, Soichi Sano, et al. · Journal of Biological Chemistry · 124
PDF
Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals
2015 · Yi-Chih Wang, Chang-seng Liang, et al. · Circulation Heart Failure · 90
PDF
Forkhead Box O-1 Modulation Improves Endothelial Insulin Resistance in Human Obesity
2015 · Shakun Karki, Melissa G. Farb, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 39
The Whitening of Brown Fat and Its Implications for Weight Management in Obesity
2015 · Ippei Shimizu, Kenneth Walsh · Current Obesity Reports · 137
Impaired Right Ventricular Hemodynamics Indicate Preclinical Pulmonary Hypertension in Patients With Metabolic Syndrome
2015 · Deepa M. Gopal, Rajalakshmi Santhanakrishnan, et al. · Journal of the American Heart Association · 41
PDF
Epicardial Adipose Tissue
2015 · Doan T. Ngo, Noyan Gokce · Circulation Cardiovascular Imaging · 13
PDF
Year
Topic