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Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic health

Description: Narrative We are all exposed to a plethora of environmental chemicals, which if they enter our bodies can have detrimental effects on function and health, but importantly can also potentially affect the health of our children and grandchildren. This project will capitalise on a unique animal model that has been established within the UK, brings together expertise from the Universities of Michigan, Glasgow (UK) and Nottingham (UK) to investigate the mechanisms by which a mother’s exposure to a real life cocktail of chemicals during pregnancy can affect the long-term metabolic and reproductive health of her offspring and that of subsequent generations.
Funding type: research
Funder scheme: R01
Start date: 2020-02-10
End date: 2025-11-30
Investigator: NEIL PRICE EVANS
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Funded outputs count: 31
Funder award ID: R01ES030374
OpenAlex ID: G5682792106
2026 · Katherine M. Littlefield, Michelle Bellingham, et al. · Environment International · 1
2026 · Oliver G Hargreaves, Wing Yee Kwong, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Katherine M HALLORAN, Yiran ZHOU, et al. · Journal of Reproduction and Development
2025 · John Dou, Soundara Viveka Thangaraj, et al. · Molecular and Cellular Endocrinology · 3
2025 · Noor Muhammad Khan, Victoria Scott, et al. · Environmental Toxicology and Pharmacology · 2
2024 · Michelle Bellingham, Neil P. Evans, et al. · Annual Review of Animal Biosciences · 11
2024 · Joseph Ciarelli, Soundara Viveka Thangaraj, et al. · Molecular and Cellular Endocrinology · 4
2023 · Mohammad Ghasemzadeh‐Hasankolaei, Chris S. Elcombe, et al. · Journal of Neuroendocrinology · 8
2023 · Vasantha Padmanabhan, Almudena Veiga-Lopez · Molecular and Cellular Endocrinology · 2
2022 · Muraly Puttabyatappa, Nadia Saadat, et al. · Toxicology and Applied Pharmacology · 21
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