Defining the interactions of senescent immune cells and skeletal cells
Description: Cellular senescence has been shown to contribute to age-related bone loss. In this project, we propose to define the interactions between senescent immune cells and skeletal cells, testing our central hypothesis that senescence of immune cells contributes to skeletal deterioration and conversely, senescent skeletal cells attract and contribute to an inflammatory and/or senescent phenotype of immune cells. In addition to defining underlying mechanisms, these studies may identify novel therapeutic targets to prevent, or reverse, age- related osteoporosis.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2022-06-01
End date: 2027-03-31
Investigator: SUNDEEP KHOSLA
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 36
Funder award ID: R01AG076515
OpenAlex ID: G9000904688